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Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles

Magnetic nanoparticles are increasingly employed in biomedical applications such as disease detection and tumor treatment. To ensure a safe and efficient operation of these applications, a noninvasive and accurate characterization of the particles is required. In this work, a magnetic characterizati...

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Autores principales: Coene, Annelies, Leliaert, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411963/
https://www.ncbi.nlm.nih.gov/pubmed/32664673
http://dx.doi.org/10.3390/s20143882
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author Coene, Annelies
Leliaert, Jonathan
author_facet Coene, Annelies
Leliaert, Jonathan
author_sort Coene, Annelies
collection PubMed
description Magnetic nanoparticles are increasingly employed in biomedical applications such as disease detection and tumor treatment. To ensure a safe and efficient operation of these applications, a noninvasive and accurate characterization of the particles is required. In this work, a magnetic characterization technique is presented in which the particles are excited by specific pulsed time-varying magnetic fields. This way, we can selectively excite nanoparticles of a given size so that the resulting measurement gives direct information on the size distribution without the need for any a priori assumptions or complex postprocessing procedures to decompose the measurement signal. This contrasts state-of-the-art magnetic characterization techniques. The possibility to selectively excite certain particle types opens up perspectives in “multicolor” particle imaging, where different particle types need to be imaged independently within one sample. Moreover, the presented methodology allows one to simultaneously determine the size-dependent coercivity of the particles. This is not only a valuable structure–property relation from a fundamental point of view, it is also practically relevant to optimize applications like magnetic particle hyperthermia. We numerically demonstrate that the novel characterization technique can accurately reconstruct several particle size distributions and is able to retrieve the coercivity–size relation of the particles. The developed technique advances current magnetic nanoparticle characterization possibilities and opens up exciting pathways for biomedical applications and particle imaging procedures.
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spelling pubmed-74119632020-08-25 Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles Coene, Annelies Leliaert, Jonathan Sensors (Basel) Article Magnetic nanoparticles are increasingly employed in biomedical applications such as disease detection and tumor treatment. To ensure a safe and efficient operation of these applications, a noninvasive and accurate characterization of the particles is required. In this work, a magnetic characterization technique is presented in which the particles are excited by specific pulsed time-varying magnetic fields. This way, we can selectively excite nanoparticles of a given size so that the resulting measurement gives direct information on the size distribution without the need for any a priori assumptions or complex postprocessing procedures to decompose the measurement signal. This contrasts state-of-the-art magnetic characterization techniques. The possibility to selectively excite certain particle types opens up perspectives in “multicolor” particle imaging, where different particle types need to be imaged independently within one sample. Moreover, the presented methodology allows one to simultaneously determine the size-dependent coercivity of the particles. This is not only a valuable structure–property relation from a fundamental point of view, it is also practically relevant to optimize applications like magnetic particle hyperthermia. We numerically demonstrate that the novel characterization technique can accurately reconstruct several particle size distributions and is able to retrieve the coercivity–size relation of the particles. The developed technique advances current magnetic nanoparticle characterization possibilities and opens up exciting pathways for biomedical applications and particle imaging procedures. MDPI 2020-07-12 /pmc/articles/PMC7411963/ /pubmed/32664673 http://dx.doi.org/10.3390/s20143882 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Coene, Annelies
Leliaert, Jonathan
Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles
title Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles
title_full Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles
title_fullStr Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles
title_full_unstemmed Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles
title_short Simultaneous Coercivity and Size Determination of Magnetic Nanoparticles
title_sort simultaneous coercivity and size determination of magnetic nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411963/
https://www.ncbi.nlm.nih.gov/pubmed/32664673
http://dx.doi.org/10.3390/s20143882
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