Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions

Screening for small-molecule fragments that can lead to potent inhibitors of protein–protein interactions (PPIs) is often a laborious step as the fragments cannot dissociate the targeted PPI due to their low μM–mM affinities. Here, we describe an NMR competition assay called w-AIDA-NMR (weak-antagon...

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Detalles Bibliográficos
Autores principales: Musielak, Bogdan, Janczyk, Weronika, Rodriguez, Ismael, Plewka, Jacek, Sala, Dominik, Magiera-Mularz, Katarzyna, Holak, Tad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412237/
https://www.ncbi.nlm.nih.gov/pubmed/32630327
http://dx.doi.org/10.3390/molecules25133017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412237/
https://www.ncbi.nlm.nih.gov/pubmed/32630327
http://dx.doi.org/10.3390/molecules25133017

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