Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a–4o), were rationally designed and synthesized. The target compounds were screened for in vitro antiproliferative efficacy in the triple-negative breast cancer (TNBC) cell line, MDA-MB-231, and normal human m...

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Detalles Bibliográficos
Autores principales: Al-Oudat, Buthina A., Ramapuram, Hariteja, Malla, Saloni, Audat, Suaad A., Hussein, Noor, Len, Jenna M., Kumari, Shikha, Bedi, Mel F., Ashby, Charles R., Tiwari, Amit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412250/
https://www.ncbi.nlm.nih.gov/pubmed/32635530
http://dx.doi.org/10.3390/molecules25133063

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