A combined CaMKII inhibition and mineralocorticoid receptor antagonism via eplerenone inhibits functional deterioration in chronic pressure overloaded mice

In the diseased and remodelled heart, increased activity and expression of Ca(2+/)calmodulin‐dependent protein kinase II (CaMKII), an excess of fibrosis, and a decreased electrical coupling and cellular excitability leads to disturbed calcium homeostasis and tissue integrity. This subsequently leads...

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Detalles Bibliográficos
Autores principales: Driessen, Helen E., Fontes, Magda S., van Stuijvenberg, Leonie, Brans, Maike A., Goumans, Marie‐Jose, Vos, Marc A., van Veen, Toon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412412/
https://www.ncbi.nlm.nih.gov/pubmed/32573944
http://dx.doi.org/10.1111/jcmm.15355

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