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In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection

In this study, we developed injectable intratympanic hyaluronic acid (HA) depots for the treatment of hearing loss. We prepared an injectable click-crosslinking formulation by modifying HA with tetrazine (HA-TET) and trans-cyclooctene (HA-TCO), which crosslinked to form an HA depot (Cx-HA). Preparat...

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Detalles Bibliográficos
Autores principales: Ju, Hyeon Jin, Park, Mina, Park, Ji Hoon, Shin, Gi Ru, Choi, Hak Soo, Suh, Myung-Whan, Kim, Moon Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412526/
https://www.ncbi.nlm.nih.gov/pubmed/32660032
http://dx.doi.org/10.3390/ma13143070