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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabric...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412548/ https://www.ncbi.nlm.nih.gov/pubmed/32605281 http://dx.doi.org/10.3390/molecules25132970 |
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author | Boobphahom, Siraprapa Nguyet Ly, Mai Soum, Veasna Pyun, Nayoon Kwon, Oh-Sun Rodthongkum, Nadnudda Shin, Kwanwoo |
author_facet | Boobphahom, Siraprapa Nguyet Ly, Mai Soum, Veasna Pyun, Nayoon Kwon, Oh-Sun Rodthongkum, Nadnudda Shin, Kwanwoo |
author_sort | Boobphahom, Siraprapa |
collection | PubMed |
description | Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented. |
format | Online Article Text |
id | pubmed-7412548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74125482020-08-26 Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening Boobphahom, Siraprapa Nguyet Ly, Mai Soum, Veasna Pyun, Nayoon Kwon, Oh-Sun Rodthongkum, Nadnudda Shin, Kwanwoo Molecules Review Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented. MDPI 2020-06-28 /pmc/articles/PMC7412548/ /pubmed/32605281 http://dx.doi.org/10.3390/molecules25132970 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boobphahom, Siraprapa Nguyet Ly, Mai Soum, Veasna Pyun, Nayoon Kwon, Oh-Sun Rodthongkum, Nadnudda Shin, Kwanwoo Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening |
title | Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening |
title_full | Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening |
title_fullStr | Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening |
title_full_unstemmed | Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening |
title_short | Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening |
title_sort | recent advances in microfluidic paper-based analytical devices toward high-throughput screening |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412548/ https://www.ncbi.nlm.nih.gov/pubmed/32605281 http://dx.doi.org/10.3390/molecules25132970 |
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