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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabric...

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Autores principales: Boobphahom, Siraprapa, Nguyet Ly, Mai, Soum, Veasna, Pyun, Nayoon, Kwon, Oh-Sun, Rodthongkum, Nadnudda, Shin, Kwanwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412548/
https://www.ncbi.nlm.nih.gov/pubmed/32605281
http://dx.doi.org/10.3390/molecules25132970
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author Boobphahom, Siraprapa
Nguyet Ly, Mai
Soum, Veasna
Pyun, Nayoon
Kwon, Oh-Sun
Rodthongkum, Nadnudda
Shin, Kwanwoo
author_facet Boobphahom, Siraprapa
Nguyet Ly, Mai
Soum, Veasna
Pyun, Nayoon
Kwon, Oh-Sun
Rodthongkum, Nadnudda
Shin, Kwanwoo
author_sort Boobphahom, Siraprapa
collection PubMed
description Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.
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spelling pubmed-74125482020-08-26 Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening Boobphahom, Siraprapa Nguyet Ly, Mai Soum, Veasna Pyun, Nayoon Kwon, Oh-Sun Rodthongkum, Nadnudda Shin, Kwanwoo Molecules Review Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented. MDPI 2020-06-28 /pmc/articles/PMC7412548/ /pubmed/32605281 http://dx.doi.org/10.3390/molecules25132970 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boobphahom, Siraprapa
Nguyet Ly, Mai
Soum, Veasna
Pyun, Nayoon
Kwon, Oh-Sun
Rodthongkum, Nadnudda
Shin, Kwanwoo
Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
title Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
title_full Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
title_fullStr Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
title_full_unstemmed Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
title_short Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening
title_sort recent advances in microfluidic paper-based analytical devices toward high-throughput screening
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412548/
https://www.ncbi.nlm.nih.gov/pubmed/32605281
http://dx.doi.org/10.3390/molecules25132970
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