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The bZIP Proteins of Oncogenic Viruses

Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization...

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Detalles Bibliográficos
Autores principales: Stolz, Madeleine L., McCormick, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412551/
https://www.ncbi.nlm.nih.gov/pubmed/32674309
http://dx.doi.org/10.3390/v12070757
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author Stolz, Madeleine L.
McCormick, Craig
author_facet Stolz, Madeleine L.
McCormick, Craig
author_sort Stolz, Madeleine L.
collection PubMed
description Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek’s disease virus (MDV), Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate.
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spelling pubmed-74125512020-08-26 The bZIP Proteins of Oncogenic Viruses Stolz, Madeleine L. McCormick, Craig Viruses Review Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek’s disease virus (MDV), Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate. MDPI 2020-07-14 /pmc/articles/PMC7412551/ /pubmed/32674309 http://dx.doi.org/10.3390/v12070757 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stolz, Madeleine L.
McCormick, Craig
The bZIP Proteins of Oncogenic Viruses
title The bZIP Proteins of Oncogenic Viruses
title_full The bZIP Proteins of Oncogenic Viruses
title_fullStr The bZIP Proteins of Oncogenic Viruses
title_full_unstemmed The bZIP Proteins of Oncogenic Viruses
title_short The bZIP Proteins of Oncogenic Viruses
title_sort bzip proteins of oncogenic viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412551/
https://www.ncbi.nlm.nih.gov/pubmed/32674309
http://dx.doi.org/10.3390/v12070757
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