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The bZIP Proteins of Oncogenic Viruses
Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412551/ https://www.ncbi.nlm.nih.gov/pubmed/32674309 http://dx.doi.org/10.3390/v12070757 |
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author | Stolz, Madeleine L. McCormick, Craig |
author_facet | Stolz, Madeleine L. McCormick, Craig |
author_sort | Stolz, Madeleine L. |
collection | PubMed |
description | Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek’s disease virus (MDV), Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate. |
format | Online Article Text |
id | pubmed-7412551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74125512020-08-26 The bZIP Proteins of Oncogenic Viruses Stolz, Madeleine L. McCormick, Craig Viruses Review Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek’s disease virus (MDV), Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate. MDPI 2020-07-14 /pmc/articles/PMC7412551/ /pubmed/32674309 http://dx.doi.org/10.3390/v12070757 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stolz, Madeleine L. McCormick, Craig The bZIP Proteins of Oncogenic Viruses |
title | The bZIP Proteins of Oncogenic Viruses |
title_full | The bZIP Proteins of Oncogenic Viruses |
title_fullStr | The bZIP Proteins of Oncogenic Viruses |
title_full_unstemmed | The bZIP Proteins of Oncogenic Viruses |
title_short | The bZIP Proteins of Oncogenic Viruses |
title_sort | bzip proteins of oncogenic viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412551/ https://www.ncbi.nlm.nih.gov/pubmed/32674309 http://dx.doi.org/10.3390/v12070757 |
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