Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation

BACKGROUND: Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF) induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models. Search for identification of toxic factor(s) in CSF revealed an enhancement in the level and enzyme activity of chitotriosidase...

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Detalles Bibliográficos
Autores principales: Varghese, Anu Mary, Ghosh, Mausam, Bhagat, Savita Kumari, Vijayalakshmi, K., Preethish-Kumar, Veeramani, Vengalil, Seena, Chevula, Pradeep-Chandra-Reddy, Nashi, Saraswati, Polavarapu, Kiran, Sharma, Meenakshi, Dhaliwal, Rupinder Singh, Philip, Mariamma, Nalini, Atchayaram, Alladi, Phalguni Anand, Sathyaprabha, Talakad N., Raju, Trichur R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412641/
https://www.ncbi.nlm.nih.gov/pubmed/32762702
http://dx.doi.org/10.1186/s12974-020-01909-y

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