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Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines

Gliomas are a group of malignant brain tumors. Despite significant efforts to optimize treatment options for patients with high-grade glioma, the prognosis of the overwhelming majority of patients remain poor. This bleak prognosis despite treatment of the glioma, is partly due to the tendency of the...

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Autores principales: Choromanska, Anna, Kulbacka, Julita, Saczko, Jolanta, Surowiak, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412714/
https://www.ncbi.nlm.nih.gov/pubmed/32802329
http://dx.doi.org/10.3892/br.2020.1339
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author Choromanska, Anna
Kulbacka, Julita
Saczko, Jolanta
Surowiak, Pawel
author_facet Choromanska, Anna
Kulbacka, Julita
Saczko, Jolanta
Surowiak, Pawel
author_sort Choromanska, Anna
collection PubMed
description Gliomas are a group of malignant brain tumors. Despite significant efforts to optimize treatment options for patients with high-grade glioma, the prognosis of the overwhelming majority of patients remain poor. This bleak prognosis despite treatment of the glioma, is partly due to the tendency of therapeutics to diffusely penetrate into the neighboring brain tissues, but also due to the innate resistance of these tumors to chemotherapy and radiation. Garlic contains water-soluble and oil-soluble sulfur compounds. The oil-soluble compounds, including diallyl sulfide, diallyl disulfide (DADS), diallyl trisulfide and ajoene, are more effective potential anti-cancer treatments than the water-soluble compounds. There are several studies examining the effects of oil-soluble compounds on various types of cancer cells, although, to the best of our knowledge, there are no studies examining the effects of these compounds on glioma cells. The aim of the present study was to investigate the potential anti-glioma properties of DAD and garlic oil on proliferation and induction of apoptosis in four different types of glioma cell lines representative of different grades of the disease. The results showed that garlic oil exhibits favorable anti-cancer potential towards gliomas of various degrees of differentiation.
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spelling pubmed-74127142020-08-14 Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines Choromanska, Anna Kulbacka, Julita Saczko, Jolanta Surowiak, Pawel Biomed Rep Articles Gliomas are a group of malignant brain tumors. Despite significant efforts to optimize treatment options for patients with high-grade glioma, the prognosis of the overwhelming majority of patients remain poor. This bleak prognosis despite treatment of the glioma, is partly due to the tendency of therapeutics to diffusely penetrate into the neighboring brain tissues, but also due to the innate resistance of these tumors to chemotherapy and radiation. Garlic contains water-soluble and oil-soluble sulfur compounds. The oil-soluble compounds, including diallyl sulfide, diallyl disulfide (DADS), diallyl trisulfide and ajoene, are more effective potential anti-cancer treatments than the water-soluble compounds. There are several studies examining the effects of oil-soluble compounds on various types of cancer cells, although, to the best of our knowledge, there are no studies examining the effects of these compounds on glioma cells. The aim of the present study was to investigate the potential anti-glioma properties of DAD and garlic oil on proliferation and induction of apoptosis in four different types of glioma cell lines representative of different grades of the disease. The results showed that garlic oil exhibits favorable anti-cancer potential towards gliomas of various degrees of differentiation. D.A. Spandidos 2020-10 2020-07-31 /pmc/articles/PMC7412714/ /pubmed/32802329 http://dx.doi.org/10.3892/br.2020.1339 Text en Copyright: © Choromanska et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Choromanska, Anna
Kulbacka, Julita
Saczko, Jolanta
Surowiak, Pawel
Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
title Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
title_full Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
title_fullStr Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
title_full_unstemmed Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
title_short Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
title_sort effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412714/
https://www.ncbi.nlm.nih.gov/pubmed/32802329
http://dx.doi.org/10.3892/br.2020.1339
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