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Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies

BACKGROUND: Activation of silent biosynthetic gene clusters (BGCs) in marine-derived actinomycete strains is a feasible strategy to discover bioactive natural products. Actinoalloteichus sp. AHMU CJ021, isolated from the seashore, was shown to contain an intact but silent caerulomycin A (CRM A) BGC-...

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Detalles Bibliográficos
Autores principales:	Xie, Yunchang, Chen, Jiawen, Wang, Bo, Chen, Tai, Chen, Junyu, Zhang, Yuan, Liu, Xiaoying, Chen, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412835/ https://www.ncbi.nlm.nih.gov/pubmed/32762690 http://dx.doi.org/10.1186/s12934-020-01418-w

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