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Aggressive multiple sclerosis (1): Towards a definition of the phenotype

While the major phenotypes of multiple sclerosis (MS) and relapsing–remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus a...

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Autores principales: Iacobaeus, Ellen, Arrambide, Georgina, Amato, Maria Pia, Derfuss, Tobias, Vukusic, Sandra, Hemmer, Bernhard, Tintore, Mar, Brundin, Lou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412876/
https://www.ncbi.nlm.nih.gov/pubmed/32530385
http://dx.doi.org/10.1177/1352458520925369
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author Iacobaeus, Ellen
Arrambide, Georgina
Amato, Maria Pia
Derfuss, Tobias
Vukusic, Sandra
Hemmer, Bernhard
Tintore, Mar
Brundin, Lou
author_facet Iacobaeus, Ellen
Arrambide, Georgina
Amato, Maria Pia
Derfuss, Tobias
Vukusic, Sandra
Hemmer, Bernhard
Tintore, Mar
Brundin, Lou
author_sort Iacobaeus, Ellen
collection PubMed
description While the major phenotypes of multiple sclerosis (MS) and relapsing–remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management.
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spelling pubmed-74128762020-08-19 Aggressive multiple sclerosis (1): Towards a definition of the phenotype Iacobaeus, Ellen Arrambide, Georgina Amato, Maria Pia Derfuss, Tobias Vukusic, Sandra Hemmer, Bernhard Tintore, Mar Brundin, Lou Mult Scler Meeting Reviews While the major phenotypes of multiple sclerosis (MS) and relapsing–remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management. SAGE Publications 2020-06-12 2020-08 /pmc/articles/PMC7412876/ /pubmed/32530385 http://dx.doi.org/10.1177/1352458520925369 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meeting Reviews
Iacobaeus, Ellen
Arrambide, Georgina
Amato, Maria Pia
Derfuss, Tobias
Vukusic, Sandra
Hemmer, Bernhard
Tintore, Mar
Brundin, Lou
Aggressive multiple sclerosis (1): Towards a definition of the phenotype
title Aggressive multiple sclerosis (1): Towards a definition of the phenotype
title_full Aggressive multiple sclerosis (1): Towards a definition of the phenotype
title_fullStr Aggressive multiple sclerosis (1): Towards a definition of the phenotype
title_full_unstemmed Aggressive multiple sclerosis (1): Towards a definition of the phenotype
title_short Aggressive multiple sclerosis (1): Towards a definition of the phenotype
title_sort aggressive multiple sclerosis (1): towards a definition of the phenotype
topic Meeting Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412876/
https://www.ncbi.nlm.nih.gov/pubmed/32530385
http://dx.doi.org/10.1177/1352458520925369
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