Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation

Inflammation-related progressive lung destruction is the leading causes of premature death in cystic fibrosis (CF), a genetic disorder caused by a defective cystic fibrosis transmembrane conductance regulator (CFTR). However, therapeutic targeting of inflammation has been hampered by a lack of under...

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Detalles Bibliográficos
Autores principales: Bernut, Audrey, Loynes, Catherine A., Floto, R. Andres, Renshaw, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412881/
https://www.ncbi.nlm.nih.gov/pubmed/32849617
http://dx.doi.org/10.3389/fimmu.2020.01733

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