Cargando…

Association of MOS-Based Blast Exposure With Medical Outcomes

The study of effects associated with human exposure to repeated low-level blast during training or operations of select military occupational specialties (MOS) challenges medical science because acute negative effects that might follow such exposures cannot be expected to be clear or prevalent. Any...

Descripción completa

Detalles Bibliográficos
Autores principales: Carr, Walter, Kelley, Amanda L., Toolin, Christine F., Weber, Natalya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413071/
https://www.ncbi.nlm.nih.gov/pubmed/32849167
http://dx.doi.org/10.3389/fneur.2020.00619
_version_ 1783568732455436288
author Carr, Walter
Kelley, Amanda L.
Toolin, Christine F.
Weber, Natalya S.
author_facet Carr, Walter
Kelley, Amanda L.
Toolin, Christine F.
Weber, Natalya S.
author_sort Carr, Walter
collection PubMed
description The study of effects associated with human exposure to repeated low-level blast during training or operations of select military occupational specialties (MOS) challenges medical science because acute negative effects that might follow such exposures cannot be expected to be clear or prevalent. Any gross effects from such occupational blast exposure on health or performance should be expected to have been already identified and addressed by affected military units through changes to their standard training protocols. Instead, effects, if any, should be expected to be incremental in nature and to vary among individuals of different susceptibilities and exposure histories. Despite the challenge, occupational blast-associated effects in humans are emerging in ongoing research. The purpose of the present study was to examine medical records for evidence of blast-associated effects that may have clinical significance in current standard of care. We hypothesized that populations exposed to blast by virtue of their military occupation would have poorer global medical outcomes than cohorts less likely to have been occupationally exposed. Records from a population of 50,254 service members in MOSs with a high likelihood of occupational blast exposure were compared to records from a matched cohort of 50,254 service members in MOSs with a lower likelihood of occupational blast exposure. These two groups were compared in hospitalizations, outpatient visits, pharmacy, and disability ratings. The clearest finding was higher risk among blast-exposed MOSs for ambulatory encounters for tinnitus, with adjusted risk ratios of 1.19 (CI 1.03–1.37), 1.21 (CI 1.16–1.26), and 1.31 (CI 1.18–1.45) across career time points. Other hypothesized effects (i.e., neurological outcomes) were smaller and were associated with acute exposure. This study documents that service members in occupations that likely include repeated exposure to blast are at some increased risk for neurosensory conditions that present in medical evaluations. Other hypothesized risks from occupational exposure may manifest as symptomology not visible in the medical system or current standard of care. Separate studies, observational and epidemiological, are underway to evaluate further the potential for occupational risk, but the evidence presented here may indicate near-term opportunities to guide efforts to reduce neurosensory risk among exposed service members.
format Online
Article
Text
id pubmed-7413071
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74130712020-08-25 Association of MOS-Based Blast Exposure With Medical Outcomes Carr, Walter Kelley, Amanda L. Toolin, Christine F. Weber, Natalya S. Front Neurol Neurology The study of effects associated with human exposure to repeated low-level blast during training or operations of select military occupational specialties (MOS) challenges medical science because acute negative effects that might follow such exposures cannot be expected to be clear or prevalent. Any gross effects from such occupational blast exposure on health or performance should be expected to have been already identified and addressed by affected military units through changes to their standard training protocols. Instead, effects, if any, should be expected to be incremental in nature and to vary among individuals of different susceptibilities and exposure histories. Despite the challenge, occupational blast-associated effects in humans are emerging in ongoing research. The purpose of the present study was to examine medical records for evidence of blast-associated effects that may have clinical significance in current standard of care. We hypothesized that populations exposed to blast by virtue of their military occupation would have poorer global medical outcomes than cohorts less likely to have been occupationally exposed. Records from a population of 50,254 service members in MOSs with a high likelihood of occupational blast exposure were compared to records from a matched cohort of 50,254 service members in MOSs with a lower likelihood of occupational blast exposure. These two groups were compared in hospitalizations, outpatient visits, pharmacy, and disability ratings. The clearest finding was higher risk among blast-exposed MOSs for ambulatory encounters for tinnitus, with adjusted risk ratios of 1.19 (CI 1.03–1.37), 1.21 (CI 1.16–1.26), and 1.31 (CI 1.18–1.45) across career time points. Other hypothesized effects (i.e., neurological outcomes) were smaller and were associated with acute exposure. This study documents that service members in occupations that likely include repeated exposure to blast are at some increased risk for neurosensory conditions that present in medical evaluations. Other hypothesized risks from occupational exposure may manifest as symptomology not visible in the medical system or current standard of care. Separate studies, observational and epidemiological, are underway to evaluate further the potential for occupational risk, but the evidence presented here may indicate near-term opportunities to guide efforts to reduce neurosensory risk among exposed service members. Frontiers Media S.A. 2020-07-31 /pmc/articles/PMC7413071/ /pubmed/32849167 http://dx.doi.org/10.3389/fneur.2020.00619 Text en This work is authored by Walter Carr, Amanda L. Kelley, Christine F. Toolin, Natalya S. Weber on behalf of the U.S. Government and, as regards Dr. Carr, Dr. Kelley, Dr. Toolin, Dr. Weber, and the U.S. Government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Carr, Walter
Kelley, Amanda L.
Toolin, Christine F.
Weber, Natalya S.
Association of MOS-Based Blast Exposure With Medical Outcomes
title Association of MOS-Based Blast Exposure With Medical Outcomes
title_full Association of MOS-Based Blast Exposure With Medical Outcomes
title_fullStr Association of MOS-Based Blast Exposure With Medical Outcomes
title_full_unstemmed Association of MOS-Based Blast Exposure With Medical Outcomes
title_short Association of MOS-Based Blast Exposure With Medical Outcomes
title_sort association of mos-based blast exposure with medical outcomes
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413071/
https://www.ncbi.nlm.nih.gov/pubmed/32849167
http://dx.doi.org/10.3389/fneur.2020.00619
work_keys_str_mv AT carrwalter associationofmosbasedblastexposurewithmedicaloutcomes
AT kelleyamandal associationofmosbasedblastexposurewithmedicaloutcomes
AT toolinchristinef associationofmosbasedblastexposurewithmedicaloutcomes
AT webernatalyas associationofmosbasedblastexposurewithmedicaloutcomes