Cargando…

The natural function of the malaria parasite’s chloroquine resistance transporter

The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the malaria parasite, yet its natural function remains unresolved. We identify host-derived peptides of 4-11 residues, varying in both charge an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413254/ https://www.ncbi.nlm.nih.gov/pubmed/32764664 http://dx.doi.org/10.1038/s41467-020-17781-6

Ejemplares similares

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter
por: Richards, Sashika N., et al.
Publicado: (2016)

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens
por: Hapuarachchi, Sanduni V., et al.
Publicado: (2017)

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
por: Shafik, Sarah Heckmatt, et al.
Publicado: (2022)

Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics
por: Cobbold, Simon A, et al.
Publicado: (2021)

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
por: Kennedy, Kit, et al.
Publicado: (2019)

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities
por: Pulcini, Serena, et al.
Publicado: (2015)

Targeting NAD(+) Metabolism in the Human Malaria Parasite Plasmodium falciparum
por: O'Hara, Jessica K., et al.
Publicado: (2014)

Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite
por: Cobbold, Simon A., et al.
Publicado: (2016)

Characterization of the Plasmodium falciparum and P. berghei glycerol 3‐phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast
por: Shears, Melanie J., et al.
Publicado: (2016)

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites
por: Srivastava, Anubhav, et al.
Publicado: (2015)

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism
por: Lewis, Ian A., et al.
Publicado: (2014)

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum
por: MacRae, James I, et al.
Publicado: (2013)

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies
por: Untaroiu, Ana M., et al.
Publicado: (2019)

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum
por: Dickerman, Benjamin K., et al.
Publicado: (2016)

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites
por: Botté, Cyrille Y., et al.
Publicado: (2011)

Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii
por: Fairweather, Stephen J., et al.
Publicado: (2021)

Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling
por: Kloehn, Joachim, et al.
Publicado: (2015)

Open questions: microbes, metabolism and host-pathogen interactions
por: McConville, Malcolm
Publicado: (2014)

Multiple Drugs Compete for Transport via the Plasmodium falciparum Chloroquine Resistance Transporter at Distinct but Interdependent Sites
por: Bellanca, Sebastiano, et al.
Publicado: (2014)

Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium
por: Husna, Asma Ul, et al.
Publicado: (2018)

Comment on “Emerging Functions of Transcription Factors in Malaria Parasite”
por: Painter, Heather J., et al.
Publicado: (2012)

The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum
por: Martin, Rowena E, et al.
Publicado: (2005)

DExSI: a new tool for the rapid quantitation of (13)C-labelled metabolites detected by GC-MS
por: Dagley, Michael J, et al.
Publicado: (2018)

Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry
por: Kloehn, Joachim, et al.
Publicado: (2021)

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
por: Amod, Leah, et al.
Publicado: (2023)

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites§
por: Hunt, Paul, et al.
Publicado: (2007)

Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology
por: Ballif, Marie, et al.
Publicado: (2010)

Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000–2016
por: Park, Seong Yeon, et al.
Publicado: (2020)

Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee
por: Zhang, Vicky, et al.
Publicado: (2019)

Evidence That Intracellular Stages of Leishmania major Utilize Amino Sugars as a Major Carbon Source
por: Naderer, Thomas, et al.
Publicado: (2010)

Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia
por: Teka, Hiwot, et al.
Publicado: (2008)

Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum
por: Painter, Heather J., et al.
Publicado: (2017)

Stress and sex in malaria parasites: Why does commitment vary?
por: Carter, Lucy M., et al.
Publicado: (2013)

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family
por: Parker, Kathryn E. R., et al.
Publicado: (2019)

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
por: Bridgford, Jessica L., et al.
Publicado: (2018)

Battling the malaria iceberg with chloroquine in India
por: Sharma, Vinod P
Publicado: (2007)

The host targeting effect of chloroquine in malaria
por: Coban, Cevayir
Publicado: (2020)

Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
por: Chu, Cindy S, et al.
Publicado: (2018)

Chloroquine-Resistant Haplotype Plasmodium falciparum Parasites, Haiti
por: Londono, Berlin L., et al.
Publicado: (2009)

Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia
por: Mekonnen, Seleshi Kebede, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ochl8sstg3ghcv6on1hqigjlgl