Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we study histone...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerrard, Dave T., Berry, Andrew A., Jennings, Rachel E., Birket, Matthew J., Zarrineh, Peyman, Garstang, Myles G., Withey, Sarah L., Short, Patrick, Jiménez-Gancedo, Sandra, Firbas, Panos N., Donaldson, Ian, Sharrocks, Andrew D., Hanley, Karen Piper, Hurles, Matthew E., Gomez-Skarmeta, José Luis, Bobola, Nicoletta, Hanley, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413392/
https://www.ncbi.nlm.nih.gov/pubmed/32764605
http://dx.doi.org/10.1038/s41467-020-17305-2

Ejemplares similares

Ejemplares similares