What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum

Erythema nodosum leprosum (ENL) is a manifestation of type II lepra reaction, seen in lepromatous or borderline lepromatous leprosy. Although it is a common reaction encountered in clinical practice, there are an increasingly large number of newer updates in the pathophysiology and management of thi...

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Detalles Bibliográficos
Autores principales: Bhat, Ramesh M., Vaidya, Tanvi P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413435/
https://www.ncbi.nlm.nih.gov/pubmed/32832433
http://dx.doi.org/10.4103/idoj.IDOJ_561_19
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author Bhat, Ramesh M.
Vaidya, Tanvi P.
author_facet Bhat, Ramesh M.
Vaidya, Tanvi P.
author_sort Bhat, Ramesh M.
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description Erythema nodosum leprosum (ENL) is a manifestation of type II lepra reaction, seen in lepromatous or borderline lepromatous leprosy. Although it is a common reaction encountered in clinical practice, there are an increasingly large number of newer updates in the pathophysiology and management of this condition. The treatment options have expanded far beyond just thalidomide and steroids and now extends to TNF-α inhibitors, thalidomide analogs, tenidap, cyclosporine A, plasma exchange, and even IVIG amongst others. These updates and the current knowledge of ENL are summarized in this review.
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spelling pubmed-74134352020-08-20 What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum Bhat, Ramesh M. Vaidya, Tanvi P. Indian Dermatol Online J Review Article Erythema nodosum leprosum (ENL) is a manifestation of type II lepra reaction, seen in lepromatous or borderline lepromatous leprosy. Although it is a common reaction encountered in clinical practice, there are an increasingly large number of newer updates in the pathophysiology and management of this condition. The treatment options have expanded far beyond just thalidomide and steroids and now extends to TNF-α inhibitors, thalidomide analogs, tenidap, cyclosporine A, plasma exchange, and even IVIG amongst others. These updates and the current knowledge of ENL are summarized in this review. Wolters Kluwer - Medknow 2020-07-13 /pmc/articles/PMC7413435/ /pubmed/32832433 http://dx.doi.org/10.4103/idoj.IDOJ_561_19 Text en Copyright: © 2020 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Bhat, Ramesh M.
Vaidya, Tanvi P.
What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum
title What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum
title_full What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum
title_fullStr What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum
title_full_unstemmed What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum
title_short What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum
title_sort what is new in the pathogenesis and management of erythema nodosum leprosum
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413435/
https://www.ncbi.nlm.nih.gov/pubmed/32832433
http://dx.doi.org/10.4103/idoj.IDOJ_561_19
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