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Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study

INTRODUCTION: Acquired dermal hyperpigmentation (ADMH) presenting on periorbital region has been described as individual case reports. We tried to characterize the features of periorbital ADMH. MATERIALS AND METHODS: This was a retrospective case-control study among our patients who attended the pig...

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Autores principales: Razmi, T. Muhammed, Thakur, Vishal, Vinay, Keshavamurthy, Aggarwal, Divya, Radotra, Bishan D., Kumaran, Muthu Sendhil, Parsad, Davinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413451/
https://www.ncbi.nlm.nih.gov/pubmed/32832448
http://dx.doi.org/10.4103/idoj.IDOJ_415_19
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author Razmi, T. Muhammed
Thakur, Vishal
Vinay, Keshavamurthy
Aggarwal, Divya
Radotra, Bishan D.
Kumaran, Muthu Sendhil
Parsad, Davinder
author_facet Razmi, T. Muhammed
Thakur, Vishal
Vinay, Keshavamurthy
Aggarwal, Divya
Radotra, Bishan D.
Kumaran, Muthu Sendhil
Parsad, Davinder
author_sort Razmi, T. Muhammed
collection PubMed
description INTRODUCTION: Acquired dermal hyperpigmentation (ADMH) presenting on periorbital region has been described as individual case reports. We tried to characterize the features of periorbital ADMH. MATERIALS AND METHODS: This was a retrospective case-control study among our patients who attended the pigmentary clinic during January 2016–December 2017. Clinical, dermoscopic, and histopathological features of subjects who were recruited during the study period were prospectively evaluated. RESULTS: Total 19 subjects (11%) were identified among 177 ADMH patients. Periorbital ADMH patients had a relatively younger age of onset (23.26 ± 11.06 vs. 36.16 ± 13.41, P < 0.001). Dermoscopy of early periorbital ADMH showed only imperceptible speckled blue-gray dots that accentuated at outer-corner creases of eyes (the “outer-corner crease sign”). Clinicopathological features and prognosis of periorbital ADMH were similar to that of ADMH per se. CONCLUSION: Periorbital ADMH should be considered as a differential diagnosis of periorbital hyperpigmentation in children and young adults. Outer-corner crease sign on dermoscopy may help to rule out other differentials in its early presentation.
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spelling pubmed-74134512020-08-20 Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study Razmi, T. Muhammed Thakur, Vishal Vinay, Keshavamurthy Aggarwal, Divya Radotra, Bishan D. Kumaran, Muthu Sendhil Parsad, Davinder Indian Dermatol Online J Brief Report INTRODUCTION: Acquired dermal hyperpigmentation (ADMH) presenting on periorbital region has been described as individual case reports. We tried to characterize the features of periorbital ADMH. MATERIALS AND METHODS: This was a retrospective case-control study among our patients who attended the pigmentary clinic during January 2016–December 2017. Clinical, dermoscopic, and histopathological features of subjects who were recruited during the study period were prospectively evaluated. RESULTS: Total 19 subjects (11%) were identified among 177 ADMH patients. Periorbital ADMH patients had a relatively younger age of onset (23.26 ± 11.06 vs. 36.16 ± 13.41, P < 0.001). Dermoscopy of early periorbital ADMH showed only imperceptible speckled blue-gray dots that accentuated at outer-corner creases of eyes (the “outer-corner crease sign”). Clinicopathological features and prognosis of periorbital ADMH were similar to that of ADMH per se. CONCLUSION: Periorbital ADMH should be considered as a differential diagnosis of periorbital hyperpigmentation in children and young adults. Outer-corner crease sign on dermoscopy may help to rule out other differentials in its early presentation. Wolters Kluwer - Medknow 2020-07-13 /pmc/articles/PMC7413451/ /pubmed/32832448 http://dx.doi.org/10.4103/idoj.IDOJ_415_19 Text en Copyright: © 2020 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Brief Report
Razmi, T. Muhammed
Thakur, Vishal
Vinay, Keshavamurthy
Aggarwal, Divya
Radotra, Bishan D.
Kumaran, Muthu Sendhil
Parsad, Davinder
Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study
title Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study
title_full Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study
title_fullStr Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study
title_full_unstemmed Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study
title_short Periorbital Acquired Dermal Macular Hyperpigmentation: A Distinctive Clinical Entity in Young Adults—Observational Case-Control Study
title_sort periorbital acquired dermal macular hyperpigmentation: a distinctive clinical entity in young adults—observational case-control study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413451/
https://www.ncbi.nlm.nih.gov/pubmed/32832448
http://dx.doi.org/10.4103/idoj.IDOJ_415_19
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