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Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study
There is growing interest in “osteosarcopenia” as the coexistence of osteoporosis and sarcopenia exacerbates negative outcomes. However, limited information is available regarding the risk factors of osteosarcopenia development in patients with osteoporosis. Therefore, we retrospectively reviewed 27...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413553/ https://www.ncbi.nlm.nih.gov/pubmed/32764814 http://dx.doi.org/10.1371/journal.pone.0237454 |
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author | Okamura, Hiroki Ishikawa, Koji Kudo, Yoshifumi Matsuoka, Akira Maruyama, Hiroshi Emori, Haruka Yamamura, Ryo Hayakawa, Chikara Tani, Soji Tsuchiya, Koki Shirahata, Toshiyuki Toyone, Tomoaki Nagai, Takashi Inagaki, Katsunori |
author_facet | Okamura, Hiroki Ishikawa, Koji Kudo, Yoshifumi Matsuoka, Akira Maruyama, Hiroshi Emori, Haruka Yamamura, Ryo Hayakawa, Chikara Tani, Soji Tsuchiya, Koki Shirahata, Toshiyuki Toyone, Tomoaki Nagai, Takashi Inagaki, Katsunori |
author_sort | Okamura, Hiroki |
collection | PubMed |
description | There is growing interest in “osteosarcopenia” as the coexistence of osteoporosis and sarcopenia exacerbates negative outcomes. However, limited information is available regarding the risk factors of osteosarcopenia development in patients with osteoporosis. Therefore, we retrospectively reviewed 276 consecutive patients with postmenopausal osteoporosis who regularly visited Showa University Hospital. Patients were eligible for the study if they were ≥65 years of age and underwent dual-energy X-ray absorptiometry, blood sampling, and physical performance assessment. Patients were divided into the osteosarcopenia and osteoporosis alone groups according to the diagnostic criteria of the Asian Working Group for Sarcopenia. Of the 276 patients with osteoporosis, 54 patients (19.6%) had osteosarcopenia. Patients in the osteosarcopenia group had a greater risk of frailty than did those in the osteoporosis alone group (odds ratio 2.33; 95% confidence interval, 1.13–4.80, P = 0.028). Low body mass index seemed to be the strongest factor related to the development of osteosarcopenia, and none of the patients in the osteosarcopenia group were obese (BMI ≥27.5 kg/m(2)). Multiple logistic analyses revealed that patients aged 65–74 years who had comorbidities such as kidney dysfunction and high levels of HbA1c were at risk of developing osteosarcopenia. Thus, we strongly recommend the assessment of the key components of the diagnosis of osteosarcopenia in an osteoporosis clinic for patients with low body mass index. Furthermore, appropriate assessments, including comorbidities, will help in identifying patients at greater risk of developing osteosarcopenia. |
format | Online Article Text |
id | pubmed-7413553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74135532020-08-13 Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study Okamura, Hiroki Ishikawa, Koji Kudo, Yoshifumi Matsuoka, Akira Maruyama, Hiroshi Emori, Haruka Yamamura, Ryo Hayakawa, Chikara Tani, Soji Tsuchiya, Koki Shirahata, Toshiyuki Toyone, Tomoaki Nagai, Takashi Inagaki, Katsunori PLoS One Research Article There is growing interest in “osteosarcopenia” as the coexistence of osteoporosis and sarcopenia exacerbates negative outcomes. However, limited information is available regarding the risk factors of osteosarcopenia development in patients with osteoporosis. Therefore, we retrospectively reviewed 276 consecutive patients with postmenopausal osteoporosis who regularly visited Showa University Hospital. Patients were eligible for the study if they were ≥65 years of age and underwent dual-energy X-ray absorptiometry, blood sampling, and physical performance assessment. Patients were divided into the osteosarcopenia and osteoporosis alone groups according to the diagnostic criteria of the Asian Working Group for Sarcopenia. Of the 276 patients with osteoporosis, 54 patients (19.6%) had osteosarcopenia. Patients in the osteosarcopenia group had a greater risk of frailty than did those in the osteoporosis alone group (odds ratio 2.33; 95% confidence interval, 1.13–4.80, P = 0.028). Low body mass index seemed to be the strongest factor related to the development of osteosarcopenia, and none of the patients in the osteosarcopenia group were obese (BMI ≥27.5 kg/m(2)). Multiple logistic analyses revealed that patients aged 65–74 years who had comorbidities such as kidney dysfunction and high levels of HbA1c were at risk of developing osteosarcopenia. Thus, we strongly recommend the assessment of the key components of the diagnosis of osteosarcopenia in an osteoporosis clinic for patients with low body mass index. Furthermore, appropriate assessments, including comorbidities, will help in identifying patients at greater risk of developing osteosarcopenia. Public Library of Science 2020-08-07 /pmc/articles/PMC7413553/ /pubmed/32764814 http://dx.doi.org/10.1371/journal.pone.0237454 Text en © 2020 Okamura et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Okamura, Hiroki Ishikawa, Koji Kudo, Yoshifumi Matsuoka, Akira Maruyama, Hiroshi Emori, Haruka Yamamura, Ryo Hayakawa, Chikara Tani, Soji Tsuchiya, Koki Shirahata, Toshiyuki Toyone, Tomoaki Nagai, Takashi Inagaki, Katsunori Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study |
title | Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study |
title_full | Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study |
title_fullStr | Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study |
title_full_unstemmed | Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study |
title_short | Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study |
title_sort | risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: a retrospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413553/ https://www.ncbi.nlm.nih.gov/pubmed/32764814 http://dx.doi.org/10.1371/journal.pone.0237454 |
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