Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al., 2017). We developed a nucleotide resolution tra...

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Detalles Bibliográficos
Autores principales: Mattijssen, Sandy, Iben, James R, Li, Tianwei, Coon, Steven L, Maraia, Richard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413741/
https://www.ncbi.nlm.nih.gov/pubmed/32744499
http://dx.doi.org/10.7554/eLife.59186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413741/
https://www.ncbi.nlm.nih.gov/pubmed/32744499
http://dx.doi.org/10.7554/eLife.59186

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