Cargando…

Regional Variation of Splicing QTLs in Human Brain

A major question in human genetics is how sequence variants of broadly expressed genes produce tissue- and cell type-specific molecular phenotypes. Genetic variation of alternative splicing is a prevalent source of transcriptomic and proteomic diversity in human populations. We investigated splicing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yida, Yang, Harry Taegyun, Kadash-Edmondson, Kathryn, Pan, Yang, Pan, Zhicheng, Davidson, Beverly L., Xing, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413857/ https://www.ncbi.nlm.nih.gov/pubmed/32589925 http://dx.doi.org/10.1016/j.ajhg.2020.06.002

Ejemplares similares

The Expanding Landscape of Alternative Splicing Variation in Human Populations
por: Park, Eddie, et al.
Publicado: (2018)

Identification of region-specific splicing QTLs in human hippocampal tissue and its distinctive role in brain disorders
por: Li, Xiaoyan, et al.
Publicado: (2023)

CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer
por: Tian, Jianbo, et al.
Publicado: (2019)

Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci
por: Takata, Atsushi, et al.
Publicado: (2017)

Alternative Splicing QTLs in European and African Populations
por: Ongen, Halit, et al.
Publicado: (2015)

isoCirc catalogs full-length circular RNA isoforms in human transcriptomes
por: Xin, Ruijiao, et al.
Publicado: (2021)

PHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells
por: Codina-Fauteux, Valérie-Anne, et al.
Publicado: (2018)

Mapping splice QTLs reveals distinct transcriptional and post-transcriptional regulatory variation of gene expression and identifies putative alternative splicing variation mediating complex trait variation in pigs
por: Zhang, Fei, et al.
Publicado: (2023)

IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
por: Pan, Yang, et al.
Publicado: (2023)

Diverse Splicing Patterns of Exonized Alu Elements in Human Tissues
por: Lin, Lan, et al.
Publicado: (2008)

ESPRESSO: Robust discovery and quantification of transcript isoforms from error-prone long-read RNA-seq data
por: Gao, Yuan, et al.
Publicado: (2023)

Genome-wide Identification and Analysis of Splicing QTLs in Multiple Sclerosis by RNA-Seq Data
por: He, Yijie, et al.
Publicado: (2021)

TEQUILA-seq: a versatile and low-cost method for targeted long-read RNA sequencing
por: Wang, Feng, et al.
Publicado: (2023)

The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells
por: Chen, Xinyuan, et al.
Publicado: (2023)

DNaseI sensitivity QTLs are a major determinant of human expression variation
por: Degner, Jacob F., et al.
Publicado: (2012)

Different sets of QTLs influence fitness variation in yeast
por: Romano, Gal Hagit, et al.
Publicado: (2010)

Allele biased transcription factor binding across human brain regions gives mechanistic insight into eQTLs
por: Moyers, Belle A., et al.
Publicado: (2023)

High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development
por: Hefti, Marco M., et al.
Publicado: (2018)

Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers
por: Phillips, John W., et al.
Publicado: (2020)

Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes
por: Hasin-Brumshtein, Yehudit, et al.
Publicado: (2016)

Utilization of natural alleles for heat adaptability QTLs at the flowering stage in rice
por: Pan, Ying-Hua, et al.
Publicado: (2023)

Genomic Analysis of QTLs and Genes Altering Natural Variation in Stochastic Noise
por: Jimenez-Gomez, Jose M., et al.
Publicado: (2011)

Deep-learning augmented RNA-seq analysis of transcript splicing
por: Zhang, Zijun, et al.
Publicado: (2019)

Genome-Wide Identification of Splicing Quantitative Trait Loci (sQTLs) in Diverse Ecotypes of Arabidopsis thaliana
por: Khokhar, Waqas, et al.
Publicado: (2019)

Splicing defects in rare diseases: transcriptomics and machine learning strategies towards genetic diagnosis
por: Wang, Robert, et al.
Publicado: (2023)

Mapping QTLs for oil traits and eQTLs for oleosin genes in jatropha
por: Liu, Peng, et al.
Publicado: (2011)

Identification of eQTLs and sQTLs associated with meat quality in beef
por: Leal-Gutiérrez, Joel D., et al.
Publicado: (2020)

Identification of QTLs and Putative Candidate Genes for Plant Architecture of Lotus Revealed by Regional Association Mapping
por: Zhao, Mei, et al.
Publicado: (2023)

seeQTL: a searchable database for human eQTLs
por: Xia, Kai, et al.
Publicado: (2012)

Genome-wide human brain eQTLs: In-depth analysis and insights using the UKBEC dataset
por: Sng, Letitia M. F., et al.
Publicado: (2019)

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci
por: Carnes, Megan Ulmer, et al.
Publicado: (2023)

Linking Metabolic QTLs with Network and cis-eQTLs Controlling Biosynthetic Pathways
por: Wentzell, Adam M, et al.
Publicado: (2007)

QTLs and eQTLs mapping related to citrandarins’ resistance to citrus gummosis disease
por: Lima, Rômulo P. M., et al.
Publicado: (2018)

Mapping of fiber quality QTLs reveals useful variation and footprints of cotton domestication using introgression lines
por: Zhang, Shu-Wen, et al.
Publicado: (2016)

Variation in alternative splicing across human tissues
por: Yeo, Gene, et al.
Publicado: (2004)

Fine mapping of the major QTLs for biochemical variation of sulforaphane in broccoli florets using a DH population
por: Li, Zhansheng, et al.
Publicado: (2021)

Discovery and characterization of variance QTLs in human induced pluripotent stem cells
por: Sarkar, Abhishek K., et al.
Publicado: (2019)

Human Expression QTLs Are Enriched in Signals of Environmental Adaptation
por: Ye, Kaixiong, et al.
Publicado: (2013)

eQTLs Regulating Transcript Variations Associated with Rapid Internode Elongation in Deepwater Rice
por: Kuroha, Takeshi, et al.
Publicado: (2017)

Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications
por: Whitbeck, J. Charles, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p3ovnpoobanpqgklb16loa39lc