Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

TP53 missense mutations leading to the expression of mutant p53 oncoproteins are frequent driver events during tumorigenesis. p53 mutants promote tumor growth, metastasis and chemoresistance by affecting fundamental cellular pathways and functions. Here, we demonstrate that p53 mutants modify struct...

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Detalles Bibliográficos
Autores principales: Capaci, Valeria, Bascetta, Lorenzo, Fantuz, Marco, Beznoussenko, Galina V., Sommaggio, Roberta, Cancila, Valeria, Bisso, Andrea, Campaner, Elena, Mironov, Alexander A., Wiśniewski, Jacek R., Ulloa Severino, Luisa, Scaini, Denis, Bossi, Fleur, Lees, Jodi, Alon, Noa, Brunga, Ledia, Malkin, David, Piazza, Silvano, Collavin, Licio, Rosato, Antonio, Bicciato, Silvio, Tripodo, Claudio, Mantovani, Fiamma, Del Sal, Giannino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414119/
https://www.ncbi.nlm.nih.gov/pubmed/32770028
http://dx.doi.org/10.1038/s41467-020-17596-5

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