Reversal of pre-existing NGFR-driven tumor and immune therapy resistance

Melanomas can switch to a dedifferentiated cell state upon exposure to cytotoxic T cells. However, it is unclear whether such tumor cells pre-exist in patients and whether they can be resensitized to immunotherapy. Here, we chronically expose (patient-derived) melanoma cell lines to differentiation...

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Detalles Bibliográficos
Autores principales: Boshuizen, Julia, Vredevoogd, David W., Krijgsman, Oscar, Ligtenberg, Maarten A., Blankenstein, Stephanie, de Bruijn, Beaunelle, Frederick, Dennie T., Kenski, Juliana C. N., Parren, Mara, Brüggemann, Marieke, Madu, Max F., Rozeman, Elisa A., Song, Ji-Ying, Horlings, Hugo M., Blank, Christian U., van Akkooi, Alexander C. J., Flaherty, Keith T., Boland, Genevieve M., Peeper, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414147/
https://www.ncbi.nlm.nih.gov/pubmed/32770055
http://dx.doi.org/10.1038/s41467-020-17739-8

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