Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication

For positive-strand RNA [(+)RNA] viruses, the major target for antiviral therapies is genomic RNA replication, which occurs at poorly understood membrane-bound viral RNA replication complexes. Recent cryoelectron microscopy (cryo-EM) of nodavirus RNA replication complexes revealed that the viral dou...

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Detalles Bibliográficos
Autores principales: Unchwaniwala, Nuruddin, Zhan, Hong, Pennington, Janice, Horswill, Mark, den Boon, Johan A., Ahlquist, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414174/
https://www.ncbi.nlm.nih.gov/pubmed/32690711
http://dx.doi.org/10.1073/pnas.2006165117

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