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Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study
BACKGROUND: Triglyceride glucose (TyG) index is a reliable marker of insulin resistance, which is linked to obstructive sleep apnea (OSA). However, the relationship between TyG index and OSA has not been adequately assessed. This study aimed to evaluate the association between TyG index and OSA. MET...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414547/ https://www.ncbi.nlm.nih.gov/pubmed/32771021 http://dx.doi.org/10.1186/s12944-020-01358-9 |
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author | Kang, Hyeon Hui Kim, Sei Won Lee, Sang Haak |
author_facet | Kang, Hyeon Hui Kim, Sei Won Lee, Sang Haak |
author_sort | Kang, Hyeon Hui |
collection | PubMed |
description | BACKGROUND: Triglyceride glucose (TyG) index is a reliable marker of insulin resistance, which is linked to obstructive sleep apnea (OSA). However, the relationship between TyG index and OSA has not been adequately assessed. This study aimed to evaluate the association between TyG index and OSA. METHODS: TyG index was assessed in 180 (mean age: 48.6 ± 13.8 years; 73.9% male) consecutive Korean adults with suspected OSA admitted to the sleep clinic at St. Paul’s Hospital between 2010 and 2012. The occurrence of more than 5 apnea-hypopnea index (AHI) events/h was used to define OSA. TyG index was calculated using the following equation: In [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. All participants were grouped according to TyG index tertiles. Multivariate logistic regression analysis was used to determine factors associated with increased OSA risk. RESULTS: The overall prevalence of OSA in study participants was determined to be 83.9%. The prevalence of OSA increased (I [lowest]: 71.6%; II: 88.7%; III [highest]: 91.4%), and lowest peripheral oxygen saturation (SpO(2)) levels decreased (I: 83.3 ± 8.5%; II: 79.9 ± 8.7%; III: 79.0 ± 8.3%), as TyG index tertile increased (P < 0.05). TyG index was correlated with AHI (r = 0.179) and lowest SpO(2) (r = − 0.188) (P < 0.05, respectively). Univariate linear regression analysis revealed an association between TyG and AHI (β = 10.084; P = 0.016). Multivariate logistic regression analysis showed that TyG index (odds ratio [OR]: 3.348; 95% confidence interval [CI]: 1.081–10.372), age ≥ 55 years (OR: 5.426; 95% CI: 1.642–17.935), and obesity (OR: 3.801; 95% CI: 1.468–9.842) were associated with increased OSA risk (all P < 0.05). The optimal TyG index cut-off value for predicting OSA was 8.83 (sensitivity: 61.6%; specificity: 69.0%; area under the curve: 0.688; P = 0.001). The predictive value of the OSA cut-off value improved when age ≥ 55 years and obesity were considered. CONCLUSION: Increased TyG index was independently associated with increased OSA risk. |
format | Online Article Text |
id | pubmed-7414547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74145472020-08-10 Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study Kang, Hyeon Hui Kim, Sei Won Lee, Sang Haak Lipids Health Dis Research BACKGROUND: Triglyceride glucose (TyG) index is a reliable marker of insulin resistance, which is linked to obstructive sleep apnea (OSA). However, the relationship between TyG index and OSA has not been adequately assessed. This study aimed to evaluate the association between TyG index and OSA. METHODS: TyG index was assessed in 180 (mean age: 48.6 ± 13.8 years; 73.9% male) consecutive Korean adults with suspected OSA admitted to the sleep clinic at St. Paul’s Hospital between 2010 and 2012. The occurrence of more than 5 apnea-hypopnea index (AHI) events/h was used to define OSA. TyG index was calculated using the following equation: In [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. All participants were grouped according to TyG index tertiles. Multivariate logistic regression analysis was used to determine factors associated with increased OSA risk. RESULTS: The overall prevalence of OSA in study participants was determined to be 83.9%. The prevalence of OSA increased (I [lowest]: 71.6%; II: 88.7%; III [highest]: 91.4%), and lowest peripheral oxygen saturation (SpO(2)) levels decreased (I: 83.3 ± 8.5%; II: 79.9 ± 8.7%; III: 79.0 ± 8.3%), as TyG index tertile increased (P < 0.05). TyG index was correlated with AHI (r = 0.179) and lowest SpO(2) (r = − 0.188) (P < 0.05, respectively). Univariate linear regression analysis revealed an association between TyG and AHI (β = 10.084; P = 0.016). Multivariate logistic regression analysis showed that TyG index (odds ratio [OR]: 3.348; 95% confidence interval [CI]: 1.081–10.372), age ≥ 55 years (OR: 5.426; 95% CI: 1.642–17.935), and obesity (OR: 3.801; 95% CI: 1.468–9.842) were associated with increased OSA risk (all P < 0.05). The optimal TyG index cut-off value for predicting OSA was 8.83 (sensitivity: 61.6%; specificity: 69.0%; area under the curve: 0.688; P = 0.001). The predictive value of the OSA cut-off value improved when age ≥ 55 years and obesity were considered. CONCLUSION: Increased TyG index was independently associated with increased OSA risk. BioMed Central 2020-08-08 /pmc/articles/PMC7414547/ /pubmed/32771021 http://dx.doi.org/10.1186/s12944-020-01358-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kang, Hyeon Hui Kim, Sei Won Lee, Sang Haak Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study |
title | Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study |
title_full | Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study |
title_fullStr | Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study |
title_full_unstemmed | Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study |
title_short | Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study |
title_sort | association between triglyceride glucose index and obstructive sleep apnea risk in korean adults: a cross-sectional cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414547/ https://www.ncbi.nlm.nih.gov/pubmed/32771021 http://dx.doi.org/10.1186/s12944-020-01358-9 |
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