Red cell–bound antibodies and transfusion requirements in hospitalized patients with COVID-19

Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react with any test cells but did react with red cells from other patients with COVID-19 that were DAT negative. This...

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Detalles Bibliográficos
Autores principales: Berzuini, Alessandra, Bianco, Cristiana, Paccapelo, Cinzia, Bertolini, Francesco, Gregato, Giuliana, Cattaneo, Alessandra, Erba, Elisa, Bandera, Alessandra, Gori, Andrea, Lamorte, Giuseppe, Manunta, Maria, Porretti, Laura, Revelli, Nicoletta, Truglio, Francesca, Grasselli, Giacomo, Zanella, Alberto, Villa, Stefania, Valenti, Luca, Prati, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2020
Materias:
Letter to Blood
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414594/
https://www.ncbi.nlm.nih.gov/pubmed/32559762
http://dx.doi.org/10.1182/blood.2020006695
Descripción
Sumario:Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react with any test cells but did react with red cells from other patients with COVID-19 that were DAT negative. This suggests that COVID-19 may modulate the red cell membrane and present novel antigenic epitopes.

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