Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

BACKGROUND: The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospinal fluid as a means for increasing rostral delivery of IT dosed radioactive tra...

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Detalles Bibliográficos
Autores principales: Sullivan, Jenna M., Mazur, Curt, Wolf, Daniel A., Horky, Laura, Currier, Nicolas, Fitzsimmons, Bethany, Hesterman, Jacob, Pauplis, Rachel, Haller, Scott, Powers, Berit, Tayefeh, Leighla, DeBrosse-Serra, Bea, Hoppin, Jack, Kordasiewicz, Holly, Swayze, Eric E., Verma, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414676/
https://www.ncbi.nlm.nih.gov/pubmed/32771027
http://dx.doi.org/10.1186/s12967-020-02461-2

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