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The dynamical model for COVID-19 with asymptotic analysis and numerical implementations

The 2019 novel coronavirus (COVID-19) emerged at the end of 2019 has a great impact on China and all over the world. The transmission mechanism of COVID-19 is still unclear. Except for the initial status and the imported cases, the isolation measures and the medical treatments of the infected patien...

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Autores principales: Liu, Jijun, Wang, Liyan, Zhang, Qiang, Yau, Shing-Tung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414781/
https://www.ncbi.nlm.nih.gov/pubmed/32836696
http://dx.doi.org/10.1016/j.apm.2020.07.057
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author Liu, Jijun
Wang, Liyan
Zhang, Qiang
Yau, Shing-Tung
author_facet Liu, Jijun
Wang, Liyan
Zhang, Qiang
Yau, Shing-Tung
author_sort Liu, Jijun
collection PubMed
description The 2019 novel coronavirus (COVID-19) emerged at the end of 2019 has a great impact on China and all over the world. The transmission mechanism of COVID-19 is still unclear. Except for the initial status and the imported cases, the isolation measures and the medical treatments of the infected patients have essential influences on the spread of COVID-19. In this paper, we establish a mathematical model for COVID-19 transmission involving the interactive effect of various factors for the infected people, including imported cases, isolating rate, diagnostic rate, recovery rate and also the mortality rate. Under the assumption that the random incubation period, the cure period and the diagnosis period are subject to the Weibull distribution, the quantity of daily existing infected people is finally governed by a linear integral-differential equation with convolution kernel. Based on the asymptotic behavior and the quantitative analysis on the model, we rigorously prove that, for limited external input patients, both the quantity of infected patients and its variation ratio will finally tend to zero, if the infected patients are sufficiently isolated or the infection rate is small enough. Finally, numerical performances for the proposed model as well as the comparisons between our simulations and the clinical data of the city Wuhan and Italy are demonstrated, showing the validity of our model with suitably specified model parameters.
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spelling pubmed-74147812020-08-10 The dynamical model for COVID-19 with asymptotic analysis and numerical implementations Liu, Jijun Wang, Liyan Zhang, Qiang Yau, Shing-Tung Appl Math Model Article The 2019 novel coronavirus (COVID-19) emerged at the end of 2019 has a great impact on China and all over the world. The transmission mechanism of COVID-19 is still unclear. Except for the initial status and the imported cases, the isolation measures and the medical treatments of the infected patients have essential influences on the spread of COVID-19. In this paper, we establish a mathematical model for COVID-19 transmission involving the interactive effect of various factors for the infected people, including imported cases, isolating rate, diagnostic rate, recovery rate and also the mortality rate. Under the assumption that the random incubation period, the cure period and the diagnosis period are subject to the Weibull distribution, the quantity of daily existing infected people is finally governed by a linear integral-differential equation with convolution kernel. Based on the asymptotic behavior and the quantitative analysis on the model, we rigorously prove that, for limited external input patients, both the quantity of infected patients and its variation ratio will finally tend to zero, if the infected patients are sufficiently isolated or the infection rate is small enough. Finally, numerical performances for the proposed model as well as the comparisons between our simulations and the clinical data of the city Wuhan and Italy are demonstrated, showing the validity of our model with suitably specified model parameters. Elsevier Inc. 2021-01 2020-08-08 /pmc/articles/PMC7414781/ /pubmed/32836696 http://dx.doi.org/10.1016/j.apm.2020.07.057 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Liu, Jijun
Wang, Liyan
Zhang, Qiang
Yau, Shing-Tung
The dynamical model for COVID-19 with asymptotic analysis and numerical implementations
title The dynamical model for COVID-19 with asymptotic analysis and numerical implementations
title_full The dynamical model for COVID-19 with asymptotic analysis and numerical implementations
title_fullStr The dynamical model for COVID-19 with asymptotic analysis and numerical implementations
title_full_unstemmed The dynamical model for COVID-19 with asymptotic analysis and numerical implementations
title_short The dynamical model for COVID-19 with asymptotic analysis and numerical implementations
title_sort dynamical model for covid-19 with asymptotic analysis and numerical implementations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414781/
https://www.ncbi.nlm.nih.gov/pubmed/32836696
http://dx.doi.org/10.1016/j.apm.2020.07.057
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