Cargando…
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
Thalamocortical dysrhythmia is a key pathology of chronic neuropathic pain, but few studies have investigated thalamocortical networks in chronic low back pain (cLBP) given its non-specific etiology and complexity. Using fMRI, we propose an analytical pipeline to identify abnormal thalamocortical ne...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414843/ https://www.ncbi.nlm.nih.gov/pubmed/32769984 http://dx.doi.org/10.1038/s41467-020-17788-z |
_version_ | 1783569052579397632 |
---|---|
author | Tu, Yiheng Fu, Zening Mao, Cuiping Falahpour, Maryam Gollub, Randy L. Park, Joel Wilson, Georgia Napadow, Vitaly Gerber, Jessica Chan, Suk-Tak Edwards, Robert R. Kaptchuk, Ted J. Liu, Thomas Calhoun, Vince Rosen, Bruce Kong, Jian |
author_facet | Tu, Yiheng Fu, Zening Mao, Cuiping Falahpour, Maryam Gollub, Randy L. Park, Joel Wilson, Georgia Napadow, Vitaly Gerber, Jessica Chan, Suk-Tak Edwards, Robert R. Kaptchuk, Ted J. Liu, Thomas Calhoun, Vince Rosen, Bruce Kong, Jian |
author_sort | Tu, Yiheng |
collection | PubMed |
description | Thalamocortical dysrhythmia is a key pathology of chronic neuropathic pain, but few studies have investigated thalamocortical networks in chronic low back pain (cLBP) given its non-specific etiology and complexity. Using fMRI, we propose an analytical pipeline to identify abnormal thalamocortical network dynamics in cLBP patients and validate the findings in two independent cohorts. We first identify two reoccurring dynamic connectivity states and their associations with chronic and temporary pain. Further analyses show that cLBP patients have abnormal connectivity between the ventral lateral/posterolateral nucleus (VL/VPL) and postcentral gyrus (PoCG) and between the dorsal/ventral medial nucleus and insula in the less frequent connectivity state, and temporary pain exacerbation alters connectivity between the VL/VPL and PoCG and the default mode network in the more frequent connectivity state. These results extend current findings on thalamocortical dysfunction and dysrhythmia in chronic pain and demonstrate that cLBP pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics. |
format | Online Article Text |
id | pubmed-7414843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74148432020-08-17 Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain Tu, Yiheng Fu, Zening Mao, Cuiping Falahpour, Maryam Gollub, Randy L. Park, Joel Wilson, Georgia Napadow, Vitaly Gerber, Jessica Chan, Suk-Tak Edwards, Robert R. Kaptchuk, Ted J. Liu, Thomas Calhoun, Vince Rosen, Bruce Kong, Jian Nat Commun Article Thalamocortical dysrhythmia is a key pathology of chronic neuropathic pain, but few studies have investigated thalamocortical networks in chronic low back pain (cLBP) given its non-specific etiology and complexity. Using fMRI, we propose an analytical pipeline to identify abnormal thalamocortical network dynamics in cLBP patients and validate the findings in two independent cohorts. We first identify two reoccurring dynamic connectivity states and their associations with chronic and temporary pain. Further analyses show that cLBP patients have abnormal connectivity between the ventral lateral/posterolateral nucleus (VL/VPL) and postcentral gyrus (PoCG) and between the dorsal/ventral medial nucleus and insula in the less frequent connectivity state, and temporary pain exacerbation alters connectivity between the VL/VPL and PoCG and the default mode network in the more frequent connectivity state. These results extend current findings on thalamocortical dysfunction and dysrhythmia in chronic pain and demonstrate that cLBP pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics. Nature Publishing Group UK 2020-08-07 /pmc/articles/PMC7414843/ /pubmed/32769984 http://dx.doi.org/10.1038/s41467-020-17788-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tu, Yiheng Fu, Zening Mao, Cuiping Falahpour, Maryam Gollub, Randy L. Park, Joel Wilson, Georgia Napadow, Vitaly Gerber, Jessica Chan, Suk-Tak Edwards, Robert R. Kaptchuk, Ted J. Liu, Thomas Calhoun, Vince Rosen, Bruce Kong, Jian Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title | Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_full | Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_fullStr | Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_full_unstemmed | Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_short | Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
title_sort | distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414843/ https://www.ncbi.nlm.nih.gov/pubmed/32769984 http://dx.doi.org/10.1038/s41467-020-17788-z |
work_keys_str_mv | AT tuyiheng distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT fuzening distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT maocuiping distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT falahpourmaryam distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT gollubrandyl distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT parkjoel distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT wilsongeorgia distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT napadowvitaly distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT gerberjessica distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT chansuktak distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT edwardsrobertr distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT kaptchuktedj distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT liuthomas distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT calhounvince distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT rosenbruce distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain AT kongjian distinctthalamocorticalnetworkdynamicsareassociatedwiththepathophysiologyofchroniclowbackpain |