Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

GABA(A)/glycine-mediated neuronal inhibition critically depends on intracellular chloride (Cl(−)) concentration which is mainly regulated by the K(+)-Cl(−) co-transporter 2 (KCC2) in the adult central nervous system (CNS). KCC2 heterogeneity thus affects information processing across CNS areas. Here...

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Detalles Bibliográficos
Autores principales: Ferrini, Francesco, Perez-Sanchez, Jimena, Ferland, Samuel, Lorenzo, Louis-Etienne, Godin, Antoine G., Plasencia-Fernandez, Isabel, Cottet, Martin, Castonguay, Annie, Wang, Feng, Salio, Chiara, Doyon, Nicolas, Merighi, Adalberto, De Koninck, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414850/
https://www.ncbi.nlm.nih.gov/pubmed/32769979
http://dx.doi.org/10.1038/s41467-020-17824-y

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