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Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes

We investigated the microvascular changes in eyes with lamellar macular holes (LMHs) using optical coherence tomography angiography (OCTA), compare them between two subtypes of LMH. Tractional and degenerative LMH were differentiated based on the morphological characteristics of OCT. In OCTA images,...

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Autores principales: Yeo, Joon Hyung, Oh, Richul, Lee, Joo Yong, Kim, June-Gone, Yoon, Young Hee, Kim, Yoon Jeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414911/
https://www.ncbi.nlm.nih.gov/pubmed/32770021
http://dx.doi.org/10.1038/s41598-020-70254-0
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author Yeo, Joon Hyung
Oh, Richul
Lee, Joo Yong
Kim, June-Gone
Yoon, Young Hee
Kim, Yoon Jeon
author_facet Yeo, Joon Hyung
Oh, Richul
Lee, Joo Yong
Kim, June-Gone
Yoon, Young Hee
Kim, Yoon Jeon
author_sort Yeo, Joon Hyung
collection PubMed
description We investigated the microvascular changes in eyes with lamellar macular holes (LMHs) using optical coherence tomography angiography (OCTA), compare them between two subtypes of LMH. Tractional and degenerative LMH were differentiated based on the morphological characteristics of OCT. In OCTA images, foveal and parafoveal vessel density (VD) in the superficial and deep capillary plexus (SCP, DCP) and foveal avascular zone (FAZ) area were measured. Eyes that underwent vitrectomy for LMH were included in subgroup analysis. We analysed 63 LMH (42 tractional and 21 degenerative) eyes and 63 control eyes. Compared with degenerative LMH, tractional LMH had better BCVA (p = 0.010), smaller FAZ area (p = 0.001), and higher foveal VD in the SCP (p = 0.130) and DCP (p = 0.002). In degenerative LMH, better BCVA was associated with greater foveal VD in the SCP (p = 0.040) and DCP (p = 0.005), and parafoveal VD in the SCP (p = 0.006). In subgroup analysis, only the tractional LMH group showed significant increases in foveal and parafoveal VDs in the SCP after vitrectomy (p = 0.001 and p = 0.026, respectively). Significant differences in microvascular changes were noted between tractional and degenerative LMH, suggesting that two subtypes are distinct pathogenetic entities.
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spelling pubmed-74149112020-08-11 Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes Yeo, Joon Hyung Oh, Richul Lee, Joo Yong Kim, June-Gone Yoon, Young Hee Kim, Yoon Jeon Sci Rep Article We investigated the microvascular changes in eyes with lamellar macular holes (LMHs) using optical coherence tomography angiography (OCTA), compare them between two subtypes of LMH. Tractional and degenerative LMH were differentiated based on the morphological characteristics of OCT. In OCTA images, foveal and parafoveal vessel density (VD) in the superficial and deep capillary plexus (SCP, DCP) and foveal avascular zone (FAZ) area were measured. Eyes that underwent vitrectomy for LMH were included in subgroup analysis. We analysed 63 LMH (42 tractional and 21 degenerative) eyes and 63 control eyes. Compared with degenerative LMH, tractional LMH had better BCVA (p = 0.010), smaller FAZ area (p = 0.001), and higher foveal VD in the SCP (p = 0.130) and DCP (p = 0.002). In degenerative LMH, better BCVA was associated with greater foveal VD in the SCP (p = 0.040) and DCP (p = 0.005), and parafoveal VD in the SCP (p = 0.006). In subgroup analysis, only the tractional LMH group showed significant increases in foveal and parafoveal VDs in the SCP after vitrectomy (p = 0.001 and p = 0.026, respectively). Significant differences in microvascular changes were noted between tractional and degenerative LMH, suggesting that two subtypes are distinct pathogenetic entities. Nature Publishing Group UK 2020-08-07 /pmc/articles/PMC7414911/ /pubmed/32770021 http://dx.doi.org/10.1038/s41598-020-70254-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yeo, Joon Hyung
Oh, Richul
Lee, Joo Yong
Kim, June-Gone
Yoon, Young Hee
Kim, Yoon Jeon
Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
title Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
title_full Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
title_fullStr Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
title_full_unstemmed Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
title_short Optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
title_sort optical coherence tomography angiographic findings of lamellar macular hole: comparisons between tractional and degenerative subtypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414911/
https://www.ncbi.nlm.nih.gov/pubmed/32770021
http://dx.doi.org/10.1038/s41598-020-70254-0
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