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ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers

Dysregulated Wnt/β-catenin activation plays a critical role in cancer progression, metastasis, and drug resistance. Genotoxic agents such as radiation and chemotherapeutics have been shown to activate the Wnt/β-catenin signaling although the underlying mechanism remains incompletely understood. Here...

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Detalles Bibliográficos
Autores principales:	Wang, Wei, Li, Mingqi, Ponnusamy, Suriyan, Chi, Yayun, Xue, Jingyan, Fahmy, Beshoy, Fan, Meiyun, Miranda-Carboni, Gustavo A., Narayanan, Ramesh, Wu, Jiong, Wu, Zhao-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414915/ https://www.ncbi.nlm.nih.gov/pubmed/32770022 http://dx.doi.org/10.1038/s41467-020-17770-9

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