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Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19

PURPOSE: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the...

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Autores principales: Carpagnano, G. E., Di Lecce, V., Quaranta, V. N., Zito, A., Buonamico, E., Capozza, E., Palumbo, A., Di Gioia, G., Valerio, V. N., Resta, O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415009/
https://www.ncbi.nlm.nih.gov/pubmed/32772324
http://dx.doi.org/10.1007/s40618-020-01370-x
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author Carpagnano, G. E.
Di Lecce, V.
Quaranta, V. N.
Zito, A.
Buonamico, E.
Capozza, E.
Palumbo, A.
Di Gioia, G.
Valerio, V. N.
Resta, O.
author_facet Carpagnano, G. E.
Di Lecce, V.
Quaranta, V. N.
Zito, A.
Buonamico, E.
Capozza, E.
Palumbo, A.
Di Gioia, G.
Valerio, V. N.
Resta, O.
author_sort Carpagnano, G. E.
collection PubMed
description PURPOSE: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis. METHODS: In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020. RESULTS: Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019). CONCLUSIONS: High prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.
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spelling pubmed-74150092020-08-10 Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19 Carpagnano, G. E. Di Lecce, V. Quaranta, V. N. Zito, A. Buonamico, E. Capozza, E. Palumbo, A. Di Gioia, G. Valerio, V. N. Resta, O. J Endocrinol Invest Original Article PURPOSE: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis. METHODS: In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020. RESULTS: Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019). CONCLUSIONS: High prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes. Springer International Publishing 2020-08-09 2021 /pmc/articles/PMC7415009/ /pubmed/32772324 http://dx.doi.org/10.1007/s40618-020-01370-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Carpagnano, G. E.
Di Lecce, V.
Quaranta, V. N.
Zito, A.
Buonamico, E.
Capozza, E.
Palumbo, A.
Di Gioia, G.
Valerio, V. N.
Resta, O.
Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
title Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
title_full Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
title_fullStr Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
title_full_unstemmed Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
title_short Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
title_sort vitamin d deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415009/
https://www.ncbi.nlm.nih.gov/pubmed/32772324
http://dx.doi.org/10.1007/s40618-020-01370-x
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