Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes

Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4(+) and CD8(+) T-cells, as well as other T-cell...

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Autores principales: Sun, Lin, Xi, Shugang, He, Guangyu, Li, Zhuo, Gang, Xiaokun, Sun, Chenglin, Guo, Weiying, Wang, Guixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415089/
https://www.ncbi.nlm.nih.gov/pubmed/32802890
http://dx.doi.org/10.1155/2020/4106518
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author Sun, Lin
Xi, Shugang
He, Guangyu
Li, Zhuo
Gang, Xiaokun
Sun, Chenglin
Guo, Weiying
Wang, Guixia
author_facet Sun, Lin
Xi, Shugang
He, Guangyu
Li, Zhuo
Gang, Xiaokun
Sun, Chenglin
Guo, Weiying
Wang, Guixia
author_sort Sun, Lin
collection PubMed
description Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4(+) and CD8(+) T-cells, as well as other T-cell subsets, could affect onset of autoimmunity. Furthermore, cells involved in innate immunity, including the macrophages, dendritic cells, and natural killer (NK) cells, could also accelerate or decelerate T1DM development. In this review, the crosstalk and function of immune cells in the pathogenesis of T1DM, as well as the corresponding therapeutic interventions, are discussed.
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spelling pubmed-74150892020-08-14 Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes Sun, Lin Xi, Shugang He, Guangyu Li, Zhuo Gang, Xiaokun Sun, Chenglin Guo, Weiying Wang, Guixia J Diabetes Res Review Article Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4(+) and CD8(+) T-cells, as well as other T-cell subsets, could affect onset of autoimmunity. Furthermore, cells involved in innate immunity, including the macrophages, dendritic cells, and natural killer (NK) cells, could also accelerate or decelerate T1DM development. In this review, the crosstalk and function of immune cells in the pathogenesis of T1DM, as well as the corresponding therapeutic interventions, are discussed. Hindawi 2020-07-30 /pmc/articles/PMC7415089/ /pubmed/32802890 http://dx.doi.org/10.1155/2020/4106518 Text en Copyright © 2020 Lin Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sun, Lin
Xi, Shugang
He, Guangyu
Li, Zhuo
Gang, Xiaokun
Sun, Chenglin
Guo, Weiying
Wang, Guixia
Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_full Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_fullStr Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_full_unstemmed Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_short Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
title_sort two to tango: dialogue between adaptive and innate immunity in type 1 diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415089/
https://www.ncbi.nlm.nih.gov/pubmed/32802890
http://dx.doi.org/10.1155/2020/4106518
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