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Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking
Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinki...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415090/ https://www.ncbi.nlm.nih.gov/pubmed/32802260 http://dx.doi.org/10.1155/2020/2497845 |
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author | Nascimento, Chirlene Pinheiro Luz, Diandra Araújo da Silva, Carla Cristiane Soares Malcher, Cláudia Marques Rosa Fernandes, Luanna Melo Pereira Dalla Santa, Herta Stutz Gomes, Antônio Rafael Quadros Monteiro, Marta Chagas Ribeiro, Carolina Heitmann Mares Azevedo Fontes-Júnior, Enéas Andrade Maia, Cristiane Socorro Ferraz |
author_facet | Nascimento, Chirlene Pinheiro Luz, Diandra Araújo da Silva, Carla Cristiane Soares Malcher, Cláudia Marques Rosa Fernandes, Luanna Melo Pereira Dalla Santa, Herta Stutz Gomes, Antônio Rafael Quadros Monteiro, Marta Chagas Ribeiro, Carolina Heitmann Mares Azevedo Fontes-Júnior, Enéas Andrade Maia, Cristiane Socorro Ferraz |
author_sort | Nascimento, Chirlene Pinheiro |
collection | PubMed |
description | Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period. In this study, we investigated whether the Aqueous Extract of G. lucidum (AEGl) reduces the behavioral disorders induced by alcohol. Male (n = 30) and female Wistar rats (n = 40), seventy-two days old, were used for behavioral/biochemical and oral toxicity test, respectively. Animals were exposed to 5 binges (beginning at 35 days old) of ethanol (3 g/kg/day) or distilled water. Twenty-four hours after the last binge administration, animals received AEGl (100 mg/kg/day) or distilled water for three consecutive days. After treatment protocol, open field, elevated plus maze, forced swim, and step-down inhibitory avoidance tests were performed. Oxidative stress parameters were measured to evaluate the REDOX balance. Our results demonstrated that AEGl elicited the recovery of spontaneous horizontal exploration capacity, anxiogenic- and depressive-profile, as well as short-term memory damage induced by binge-ethanol exposure. The behavioral effects of the extract were associated to the reequilibrium of the animals' REDOX balance. Thus, AEGl, a medicinal mushroom, ameliorates behavioral alteration on a model of motor, cognitive and psychiatric-like disorders induced by binge drinking paradigm and emerges as a useful tool as a food supplement in the management of disorders of alcoholic origin. |
format | Online Article Text |
id | pubmed-7415090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-74150902020-08-14 Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking Nascimento, Chirlene Pinheiro Luz, Diandra Araújo da Silva, Carla Cristiane Soares Malcher, Cláudia Marques Rosa Fernandes, Luanna Melo Pereira Dalla Santa, Herta Stutz Gomes, Antônio Rafael Quadros Monteiro, Marta Chagas Ribeiro, Carolina Heitmann Mares Azevedo Fontes-Júnior, Enéas Andrade Maia, Cristiane Socorro Ferraz Oxid Med Cell Longev Research Article Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period. In this study, we investigated whether the Aqueous Extract of G. lucidum (AEGl) reduces the behavioral disorders induced by alcohol. Male (n = 30) and female Wistar rats (n = 40), seventy-two days old, were used for behavioral/biochemical and oral toxicity test, respectively. Animals were exposed to 5 binges (beginning at 35 days old) of ethanol (3 g/kg/day) or distilled water. Twenty-four hours after the last binge administration, animals received AEGl (100 mg/kg/day) or distilled water for three consecutive days. After treatment protocol, open field, elevated plus maze, forced swim, and step-down inhibitory avoidance tests were performed. Oxidative stress parameters were measured to evaluate the REDOX balance. Our results demonstrated that AEGl elicited the recovery of spontaneous horizontal exploration capacity, anxiogenic- and depressive-profile, as well as short-term memory damage induced by binge-ethanol exposure. The behavioral effects of the extract were associated to the reequilibrium of the animals' REDOX balance. Thus, AEGl, a medicinal mushroom, ameliorates behavioral alteration on a model of motor, cognitive and psychiatric-like disorders induced by binge drinking paradigm and emerges as a useful tool as a food supplement in the management of disorders of alcoholic origin. Hindawi 2020-07-30 /pmc/articles/PMC7415090/ /pubmed/32802260 http://dx.doi.org/10.1155/2020/2497845 Text en Copyright © 2020 Chirlene Pinheiro Nascimento et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nascimento, Chirlene Pinheiro Luz, Diandra Araújo da Silva, Carla Cristiane Soares Malcher, Cláudia Marques Rosa Fernandes, Luanna Melo Pereira Dalla Santa, Herta Stutz Gomes, Antônio Rafael Quadros Monteiro, Marta Chagas Ribeiro, Carolina Heitmann Mares Azevedo Fontes-Júnior, Enéas Andrade Maia, Cristiane Socorro Ferraz Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking |
title |
Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking |
title_full |
Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking |
title_fullStr |
Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking |
title_full_unstemmed |
Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking |
title_short |
Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking |
title_sort | ganoderma lucidum ameliorates neurobehavioral changes and oxidative stress induced by ethanol binge drinking |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415090/ https://www.ncbi.nlm.nih.gov/pubmed/32802260 http://dx.doi.org/10.1155/2020/2497845 |
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