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Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis

A 38-year-old hypertensive male with a smoking history presented to the emergency room with significant hemoptysis, arthritis, and a purpuric rash. Other findings included a dropping hemoglobin and acute kidney injury with microscopic hematuria. The pulmonary computed tomography was significant for...

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Detalles Bibliográficos
Autores principales: Alhazmi, Ahmed, Cheikh, Mohamed Moulaye, Hassan, Rola Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415123/
https://www.ncbi.nlm.nih.gov/pubmed/32802546
http://dx.doi.org/10.1155/2020/3079869
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author Alhazmi, Ahmed
Cheikh, Mohamed Moulaye
Hassan, Rola Yousef
author_facet Alhazmi, Ahmed
Cheikh, Mohamed Moulaye
Hassan, Rola Yousef
author_sort Alhazmi, Ahmed
collection PubMed
description A 38-year-old hypertensive male with a smoking history presented to the emergency room with significant hemoptysis, arthritis, and a purpuric rash. Other findings included a dropping hemoglobin and acute kidney injury with microscopic hematuria. The pulmonary computed tomography was significant for alveolar hemorrhage and a rarely reported pneumomediastinum. Along with this constellation of findings, a positive antiproteinase 3 helped to confirm this patient's diagnosis of granulomatosis with polyangiitis. Treatment commenced with sessions of plasma exchange and pulse steroids along with cyclophosphamide infusions. The patient had since improved and made a full recovery. This case report highlights the rarely described pneumomediastinum in association with vasculitides.
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spelling pubmed-74151232020-08-14 Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis Alhazmi, Ahmed Cheikh, Mohamed Moulaye Hassan, Rola Yousef Case Rep Rheumatol Case Report A 38-year-old hypertensive male with a smoking history presented to the emergency room with significant hemoptysis, arthritis, and a purpuric rash. Other findings included a dropping hemoglobin and acute kidney injury with microscopic hematuria. The pulmonary computed tomography was significant for alveolar hemorrhage and a rarely reported pneumomediastinum. Along with this constellation of findings, a positive antiproteinase 3 helped to confirm this patient's diagnosis of granulomatosis with polyangiitis. Treatment commenced with sessions of plasma exchange and pulse steroids along with cyclophosphamide infusions. The patient had since improved and made a full recovery. This case report highlights the rarely described pneumomediastinum in association with vasculitides. Hindawi 2020-07-30 /pmc/articles/PMC7415123/ /pubmed/32802546 http://dx.doi.org/10.1155/2020/3079869 Text en Copyright © 2020 Ahmed Alhazmi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alhazmi, Ahmed
Cheikh, Mohamed Moulaye
Hassan, Rola Yousef
Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis
title Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis
title_full Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis
title_fullStr Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis
title_full_unstemmed Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis
title_short Pneumomediastinum as a Manifestation of Granulomatosis with Polyangiitis
title_sort pneumomediastinum as a manifestation of granulomatosis with polyangiitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415123/
https://www.ncbi.nlm.nih.gov/pubmed/32802546
http://dx.doi.org/10.1155/2020/3079869
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