Cargando…

Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury

INTRODUCTION: Astrogliosis and glial scar formation following spinal cord injury (SCI) are viewed as major obstacles that hinder axonal regeneration and functional recovery. Regulating the glial scar and axonal regeneration in the lesion site is important for treating SCI. AIMS: Considering the impo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Xianpeng, Wang, Chenggui, Zhou, Xiaopeng, Wang, Jingkai, Xia, Kaishun, Yang, Biao, Gong, Zhe, Ying, Liwei, Yu, Chao, Shi, Kesi, Shu, Jiawei, Cheng, Feng, Han, Bin, Liang, Chengzhen, Li, Fangcai, Chen, Qixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415207/ https://www.ncbi.nlm.nih.gov/pubmed/32449258 http://dx.doi.org/10.1111/cns.13390

Ejemplares similares

An injectable heparin-Laponite hydrogel bridge FGF4 for spinal cord injury by stabilizing microtubule and improving mitochondrial function
por: Wang, Chenggui, et al.
Publicado: (2019)

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury
por: Yang, Biao, et al.
Publicado: (2020)

A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair
por: Yang, Biao, et al.
Publicado: (2021)

Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration
por: Zhang, Yuang, et al.
Publicado: (2020)

A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury
por: Wang, Chenggui, et al.
Publicado: (2021)

Thermosensitive hydrogel‐based GPR124 delivery strategy for rebuilding blood‐spinal cord barrier
por: Shu, Jiawei, et al.
Publicado: (2023)

Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch
por: Cheng, Feng, et al.
Publicado: (2022)

Advances in single‐cell sequencing and its application to musculoskeletal system research
por: Zhang, Yongxiang, et al.
Publicado: (2021)

Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell
por: Yu, Chao, et al.
Publicado: (2021)

Micro Fragmented Adipose Tissue Promotes the Matrix Synthesis Function of Nucleus Pulposus Cells and Regenerates Degenerated Intervertebral Disc in a Pig Model
por: Zhou, Xiaopeng, et al.
Publicado: (2020)

Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy
por: Li, Yi, et al.
Publicado: (2023)

Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration
por: Xia, Kaishun, et al.
Publicado: (2019)

Counteracting Activities of OCT4 and KLF4 during Reprogramming to Pluripotency
por: Tiemann, Ulf, et al.
Publicado: (2014)

Expression and Functional Analysis of core stemness factors OSKM (OCT4, SOX2, KLF4, and MYC) in Pan-cancer
por: Hong, Liwei, et al.
Publicado: (2023)

Small Molecule-Based Strategy Promotes Nucleus Pulposus Specific Differentiation of Adipose-Derived Mesenchymal Stem Cells
por: Hua, Jianming, et al.
Publicado: (2019)

Protein Expression of PTTG-1, OCT-4, and KLF-4 in Seminoma: A Pilot Study
por: Grande, Giuseppe, et al.
Publicado: (2019)

Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc
por: Liang, Chengzhen, et al.
Publicado: (2012)

Cervical Total Disc Replacement is Superior to Anterior Cervical Decompression and Fusion: A Meta-Analysis of Prospective Randomized Controlled Trials
por: Zhang, Yujie, et al.
Publicado: (2015)

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
por: Zhu, Jian, et al.
Publicado: (2019)

Radiological manifestations and surgical outcome of combined upper cervical cord compression and cervical ossification of the posterior longitudinal ligament with a minimum 2-year follow-up
por: Li, Hao, et al.
Publicado: (2017)

Application of the Yamanaka Transcription Factors Oct4, Sox2, Klf4, and c-Myc from the Laboratory to the Clinic
por: Aguirre, Marisol, et al.
Publicado: (2023)

KLF4 overexpression decreases the viability, invasion and migration of papillary thyroid cancer cells
por: Wang, Qianzhu, et al.
Publicado: (2019)

Gene expression of OCT4, SOX2, KLF4 and MYC (OSKM) induced pluripotent stem cells: identification for potential mechanisms
por: Cai, Yanning, et al.
Publicado: (2015)

Improvement of non-alcoholic steatohepatitis by hepatocyte-like cells generated from iPSCs with Oct4/Sox2/Klf4/Parp1
por: Chien, Yueh, et al.
Publicado: (2018)

Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4
por: Corbineau, Sébastien, et al.
Publicado: (2016)

Evaluation of the Effect of Orlistatorlistat on Expression of OCT4, Nanog, SOX2, and KLF4 Genes in Colorectal Cancer SW40 Cell Line
por: Noroozi Karimabad, Mojgan, et al.
Publicado: (2021)

The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors
por: Li, Jun-Chen, et al.
Publicado: (2021)

CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo
por: Xu, Xin, et al.
Publicado: (2017)

The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
por: Schmidt, Ryan, et al.
Publicado: (2012)

Increases in iPS Transcription Factor (Oct4, Sox2, c-Myc, and Klf4) Gene Expression after Modified Electroconvulsive Therapy
por: Nishiguchi, Masaki, et al.
Publicado: (2015)

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis
por: Alencar, Gabriel F., et al.
Publicado: (2020)

Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma
por: Wang, Yitian, et al.
Publicado: (2019)

EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α
por: Kuan, I.-I., et al.
Publicado: (2017)

KLF4α stimulates breast cancer cell proliferation by acting as a KLF4 antagonist
por: Ferralli, Jacqueline, et al.
Publicado: (2016)

NBMA Promotes Spermatogenesis by Mediating Oct4 Pathway
por: Yang, Jinfei, et al.
Publicado: (2022)

Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway
por: Xu, Qing, et al.
Publicado: (2016)

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness
por: Lee, Sung-Hun, et al.
Publicado: (2016)

The Role of KLF(4) in Alzheimer’s Disease
por: Cheng, Ziqian, et al.
Publicado: (2018)

KLF4 transcription factor in tumorigenesis
por: He, Zhihong, et al.
Publicado: (2023)

Overexpression of OCT4A ortholog elevates endogenous XIST in porcine parthenogenic blastocysts
por: HWANG, Jae Yeon, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7nmp7ea0uvuk57j67q1rvgfech