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Distant supervision for medical concept normalization

We consider the task of Medical Concept Normalization (MCN) which aims to map informal medical phrases such as “loosing weight” to formal medical concepts, such as “Weight loss”. Deep learning models have shown high performance across various MCN datasets containing small number of target concepts a...

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Autores principales: Pattisapu, Nikhil, Anand, Vivek, Patil, Sangameshwar, Palshikar, Girish, Varma, Vasudeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415240/
https://www.ncbi.nlm.nih.gov/pubmed/32783923
http://dx.doi.org/10.1016/j.jbi.2020.103522
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author Pattisapu, Nikhil
Anand, Vivek
Patil, Sangameshwar
Palshikar, Girish
Varma, Vasudeva
author_facet Pattisapu, Nikhil
Anand, Vivek
Patil, Sangameshwar
Palshikar, Girish
Varma, Vasudeva
author_sort Pattisapu, Nikhil
collection PubMed
description We consider the task of Medical Concept Normalization (MCN) which aims to map informal medical phrases such as “loosing weight” to formal medical concepts, such as “Weight loss”. Deep learning models have shown high performance across various MCN datasets containing small number of target concepts along with adequate number of training examples per concept. However, scaling these models to millions of medical concepts entails the creation of much larger datasets which is cost and effort intensive. Recent works have shown that training MCN models using automatically labeled examples extracted from medical knowledge bases partially alleviates this problem. We extend this idea by computationally creating a distant dataset from patient discussion forums. We extract informal medical phrases and medical concepts from these forums using a synthetically trained classifier and an off-the-shelf medical entity linker respectively. We use pretrained sentence encoding models to find the k-nearest phrases corresponding to each medical concept. These mappings are used in combination with the examples obtained from medical knowledge bases to train an MCN model. Our approach outperforms the previous state-of-the-art by 15.9% and 17.1% classification accuracy across two datasets while avoiding manual labeling.
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spelling pubmed-74152402020-08-10 Distant supervision for medical concept normalization Pattisapu, Nikhil Anand, Vivek Patil, Sangameshwar Palshikar, Girish Varma, Vasudeva J Biomed Inform Original Research We consider the task of Medical Concept Normalization (MCN) which aims to map informal medical phrases such as “loosing weight” to formal medical concepts, such as “Weight loss”. Deep learning models have shown high performance across various MCN datasets containing small number of target concepts along with adequate number of training examples per concept. However, scaling these models to millions of medical concepts entails the creation of much larger datasets which is cost and effort intensive. Recent works have shown that training MCN models using automatically labeled examples extracted from medical knowledge bases partially alleviates this problem. We extend this idea by computationally creating a distant dataset from patient discussion forums. We extract informal medical phrases and medical concepts from these forums using a synthetically trained classifier and an off-the-shelf medical entity linker respectively. We use pretrained sentence encoding models to find the k-nearest phrases corresponding to each medical concept. These mappings are used in combination with the examples obtained from medical knowledge bases to train an MCN model. Our approach outperforms the previous state-of-the-art by 15.9% and 17.1% classification accuracy across two datasets while avoiding manual labeling. Elsevier Inc. 2020-09 2020-08-09 /pmc/articles/PMC7415240/ /pubmed/32783923 http://dx.doi.org/10.1016/j.jbi.2020.103522 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Research
Pattisapu, Nikhil
Anand, Vivek
Patil, Sangameshwar
Palshikar, Girish
Varma, Vasudeva
Distant supervision for medical concept normalization
title Distant supervision for medical concept normalization
title_full Distant supervision for medical concept normalization
title_fullStr Distant supervision for medical concept normalization
title_full_unstemmed Distant supervision for medical concept normalization
title_short Distant supervision for medical concept normalization
title_sort distant supervision for medical concept normalization
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415240/
https://www.ncbi.nlm.nih.gov/pubmed/32783923
http://dx.doi.org/10.1016/j.jbi.2020.103522
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