Potential of transposon-mediated cellular reprogramming towards cell-based therapies

Induced pluripotent stem (iPS) cells present a seminal discovery in cell biology and promise to support innovative treatments of so far incurable diseases. To translate iPS technology into clinical trials, the safety and stability of these reprogrammed cells needs to be shown. In recent years, diffe...

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Autores principales: Kumar, Dharmendra, Anand, Taruna, Talluri, Thirumala R, Kues, Wilfried A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415244/
https://www.ncbi.nlm.nih.gov/pubmed/32843912
http://dx.doi.org/10.4252/wjsc.v12.i7.527
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author Kumar, Dharmendra
Anand, Taruna
Talluri, Thirumala R
Kues, Wilfried A
author_facet Kumar, Dharmendra
Anand, Taruna
Talluri, Thirumala R
Kues, Wilfried A
author_sort Kumar, Dharmendra
collection PubMed
description Induced pluripotent stem (iPS) cells present a seminal discovery in cell biology and promise to support innovative treatments of so far incurable diseases. To translate iPS technology into clinical trials, the safety and stability of these reprogrammed cells needs to be shown. In recent years, different non-viral transposon systems have been developed for the induction of cellular pluripotency, and for the directed differentiation into desired cell types. In this review, we summarize the current state of the art of different transposon systems in iPS-based cell therapies.
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spelling pubmed-74152442020-08-24 Potential of transposon-mediated cellular reprogramming towards cell-based therapies Kumar, Dharmendra Anand, Taruna Talluri, Thirumala R Kues, Wilfried A World J Stem Cells Review Induced pluripotent stem (iPS) cells present a seminal discovery in cell biology and promise to support innovative treatments of so far incurable diseases. To translate iPS technology into clinical trials, the safety and stability of these reprogrammed cells needs to be shown. In recent years, different non-viral transposon systems have been developed for the induction of cellular pluripotency, and for the directed differentiation into desired cell types. In this review, we summarize the current state of the art of different transposon systems in iPS-based cell therapies. Baishideng Publishing Group Inc 2020-07-26 2020-07-26 /pmc/articles/PMC7415244/ /pubmed/32843912 http://dx.doi.org/10.4252/wjsc.v12.i7.527 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Kumar, Dharmendra
Anand, Taruna
Talluri, Thirumala R
Kues, Wilfried A
Potential of transposon-mediated cellular reprogramming towards cell-based therapies
title Potential of transposon-mediated cellular reprogramming towards cell-based therapies
title_full Potential of transposon-mediated cellular reprogramming towards cell-based therapies
title_fullStr Potential of transposon-mediated cellular reprogramming towards cell-based therapies
title_full_unstemmed Potential of transposon-mediated cellular reprogramming towards cell-based therapies
title_short Potential of transposon-mediated cellular reprogramming towards cell-based therapies
title_sort potential of transposon-mediated cellular reprogramming towards cell-based therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415244/
https://www.ncbi.nlm.nih.gov/pubmed/32843912
http://dx.doi.org/10.4252/wjsc.v12.i7.527
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