Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus

Syndromic respiratory panels are increasingly used worldwide. Their performance for detection of Bordetella pertussis needs to be evaluated. We found that the FilmArray Respiratory Panel 2plus (RP2+) assay, which uses the pertussis toxin promoter target for B. pertussis, can only detect highly charg...

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Detalles Bibliográficos
Autores principales: Guillot, Sophie, Mizrahi, Assaf, Armatys, Nathalie, Chat, Laureen, Le Monnier, Alban, Brisse, Sylvain, Toubiana, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415305/
https://www.ncbi.nlm.nih.gov/pubmed/32793765
http://dx.doi.org/10.1093/ofid/ofaa267
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author Guillot, Sophie
Mizrahi, Assaf
Armatys, Nathalie
Chat, Laureen
Le Monnier, Alban
Brisse, Sylvain
Toubiana, Julie
author_facet Guillot, Sophie
Mizrahi, Assaf
Armatys, Nathalie
Chat, Laureen
Le Monnier, Alban
Brisse, Sylvain
Toubiana, Julie
author_sort Guillot, Sophie
collection PubMed
description Syndromic respiratory panels are increasingly used worldwide. Their performance for detection of Bordetella pertussis needs to be evaluated. We found that the FilmArray Respiratory Panel 2plus (RP2+) assay, which uses the pertussis toxin promoter target for B. pertussis, can only detect highly charged samples. Negative RP2+ results should not be interpreted as an absence of B. pertussis in clinical samples.
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spelling pubmed-74153052020-08-12 Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus Guillot, Sophie Mizrahi, Assaf Armatys, Nathalie Chat, Laureen Le Monnier, Alban Brisse, Sylvain Toubiana, Julie Open Forum Infect Dis Brief Reports Syndromic respiratory panels are increasingly used worldwide. Their performance for detection of Bordetella pertussis needs to be evaluated. We found that the FilmArray Respiratory Panel 2plus (RP2+) assay, which uses the pertussis toxin promoter target for B. pertussis, can only detect highly charged samples. Negative RP2+ results should not be interpreted as an absence of B. pertussis in clinical samples. Oxford University Press 2020-07-02 /pmc/articles/PMC7415305/ /pubmed/32793765 http://dx.doi.org/10.1093/ofid/ofaa267 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Guillot, Sophie
Mizrahi, Assaf
Armatys, Nathalie
Chat, Laureen
Le Monnier, Alban
Brisse, Sylvain
Toubiana, Julie
Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus
title Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus
title_full Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus
title_fullStr Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus
title_full_unstemmed Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus
title_short Low Detection Rate of Bordetella pertussis Using the BioFire FilmArray Respiratory Panel 2plus
title_sort low detection rate of bordetella pertussis using the biofire filmarray respiratory panel 2plus
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415305/
https://www.ncbi.nlm.nih.gov/pubmed/32793765
http://dx.doi.org/10.1093/ofid/ofaa267
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