HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM

PURPOSE: Herpes simplex virus type I (HSV-1) infection of corneal epithelial cells activates ataxia telangiectasia mutated (ATM), an apical kinase in the host DNA damage response pathway, whose activity is necessary for the progression of lytic HSV-1 infection. The purpose of this study is to invest...

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Detalles Bibliográficos
Autores principales: Alekseev, Oleg, Donegan, William E., Donovan, Kelly R., Limonnik, Vladimir, Azizkhan-Clifford, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Immunology and Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415316/
https://www.ncbi.nlm.nih.gov/pubmed/32543665
http://dx.doi.org/10.1167/iovs.61.6.39

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