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Role of Damage-Associated Molecular Patterns in Light of Modern Environmental Research: A Tautological Approach
Two prominent models emerged as a result of intense interdisciplinary discussions on the environmental health paradigm, called the “exposome” concept and the “adverse outcome pathway” (AOP) concept that links a molecular initiating event to the adverse outcome via key events. Here, evidence is discu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415330/ https://www.ncbi.nlm.nih.gov/pubmed/32837525 http://dx.doi.org/10.1007/s41742-020-00276-z |
Sumario: | Two prominent models emerged as a result of intense interdisciplinary discussions on the environmental health paradigm, called the “exposome” concept and the “adverse outcome pathway” (AOP) concept that links a molecular initiating event to the adverse outcome via key events. Here, evidence is discussed, suggesting that environmental stress/injury-induced damage-associated molecular patterns (DAMPs) may operate as an essential integrating element of both environmental health research paradigms. DAMP-promoted controlled/uncontrolled innate/adaptive immune responses reflect the key events of the AOP concept. The whole process starting from exposure to a distinct environmental stress/injury—associated with the presence/emission of DAMPs—up to the manifestation of a disease may be regarded as an exposome. Clinical examples of such a scenario are briefly sketched, in particular, a model in relation to the emerging COVID-19 pandemic, where the interaction of noninfectious environmental factors (e.g., particulate matter) and infectious factors (SARS CoV-2) may promote SARS case fatality via superimposition of both exogenous and endogenous DAMPs. |
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