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Resveratrol reduces inflammation-related Prostate Fibrosis
Inflammation-related prostate fibrosis (PF) is strongly associated with impaired urethral function and lower urinary tract symptoms (LUTS) severity. The aim of this study was to investigate the effects of RSV in patients with small prostate volume and LUTS. Sixty-four patients with PF were randomize...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415386/ https://www.ncbi.nlm.nih.gov/pubmed/32788865 http://dx.doi.org/10.7150/ijms.44443 |
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author | Vicari, Enzo Arancio, Alessandro Catania, Vito Emanuele Vicari, Beatrice Ornella Sidoti, Giuseppe Castiglione, Roberto Malaguarnera, Michele |
author_facet | Vicari, Enzo Arancio, Alessandro Catania, Vito Emanuele Vicari, Beatrice Ornella Sidoti, Giuseppe Castiglione, Roberto Malaguarnera, Michele |
author_sort | Vicari, Enzo |
collection | PubMed |
description | Inflammation-related prostate fibrosis (PF) is strongly associated with impaired urethral function and lower urinary tract symptoms (LUTS) severity. The aim of this study was to investigate the effects of RSV in patients with small prostate volume and LUTS. Sixty-four patients with PF were randomized either to RSV therapy (group A= 32 patients) or placebo (group B= 32 patients). At baseline (T0) and after 2-months (T2), patients of both groups underwent administration of NIH-Chronic Prostatic Symptom Index (NIH-CPSI) and International Prostate Symptom Score (IPSS) questionnaires for prostatitis and LUTS, respectively, and Expressed Prostatic Secretion (EPS) assays. After two months, only, group A patients treated with RSV showed significant symptomatic improvement of all NIH-CPSI and IPSS subscale scores, as well as a better EPS assay after prostate massage, in terms of high amount of prostatic volume and reduced white blood cells counts. Our data suggested pharmacological advantage after 2-month treatment with RSV in selected patients with PF for the treatment of voiding and storage complaints. |
format | Online Article Text |
id | pubmed-7415386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-74153862020-08-11 Resveratrol reduces inflammation-related Prostate Fibrosis Vicari, Enzo Arancio, Alessandro Catania, Vito Emanuele Vicari, Beatrice Ornella Sidoti, Giuseppe Castiglione, Roberto Malaguarnera, Michele Int J Med Sci Research Paper Inflammation-related prostate fibrosis (PF) is strongly associated with impaired urethral function and lower urinary tract symptoms (LUTS) severity. The aim of this study was to investigate the effects of RSV in patients with small prostate volume and LUTS. Sixty-four patients with PF were randomized either to RSV therapy (group A= 32 patients) or placebo (group B= 32 patients). At baseline (T0) and after 2-months (T2), patients of both groups underwent administration of NIH-Chronic Prostatic Symptom Index (NIH-CPSI) and International Prostate Symptom Score (IPSS) questionnaires for prostatitis and LUTS, respectively, and Expressed Prostatic Secretion (EPS) assays. After two months, only, group A patients treated with RSV showed significant symptomatic improvement of all NIH-CPSI and IPSS subscale scores, as well as a better EPS assay after prostate massage, in terms of high amount of prostatic volume and reduced white blood cells counts. Our data suggested pharmacological advantage after 2-month treatment with RSV in selected patients with PF for the treatment of voiding and storage complaints. Ivyspring International Publisher 2020-07-19 /pmc/articles/PMC7415386/ /pubmed/32788865 http://dx.doi.org/10.7150/ijms.44443 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Vicari, Enzo Arancio, Alessandro Catania, Vito Emanuele Vicari, Beatrice Ornella Sidoti, Giuseppe Castiglione, Roberto Malaguarnera, Michele Resveratrol reduces inflammation-related Prostate Fibrosis |
title | Resveratrol reduces inflammation-related Prostate Fibrosis |
title_full | Resveratrol reduces inflammation-related Prostate Fibrosis |
title_fullStr | Resveratrol reduces inflammation-related Prostate Fibrosis |
title_full_unstemmed | Resveratrol reduces inflammation-related Prostate Fibrosis |
title_short | Resveratrol reduces inflammation-related Prostate Fibrosis |
title_sort | resveratrol reduces inflammation-related prostate fibrosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415386/ https://www.ncbi.nlm.nih.gov/pubmed/32788865 http://dx.doi.org/10.7150/ijms.44443 |
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