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Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China
Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415392/ https://www.ncbi.nlm.nih.gov/pubmed/32788884 http://dx.doi.org/10.7150/ijms.47935 |
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author | Xu, Xia Yu, Mu-Qing Shen, Qian Wang, Lian-Zhong Yan, Rong-Di Zhang, Meng-Yu Liu, Jian-Yu Qu, Yi-Qing |
author_facet | Xu, Xia Yu, Mu-Qing Shen, Qian Wang, Lian-Zhong Yan, Rong-Di Zhang, Meng-Yu Liu, Jian-Yu Qu, Yi-Qing |
author_sort | Xu, Xia |
collection | PubMed |
description | Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ±15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity. Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient. |
format | Online Article Text |
id | pubmed-7415392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-74153922020-08-11 Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China Xu, Xia Yu, Mu-Qing Shen, Qian Wang, Lian-Zhong Yan, Rong-Di Zhang, Meng-Yu Liu, Jian-Yu Qu, Yi-Qing Int J Med Sci Research Paper Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ±15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity. Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient. Ivyspring International Publisher 2020-07-25 /pmc/articles/PMC7415392/ /pubmed/32788884 http://dx.doi.org/10.7150/ijms.47935 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Xu, Xia Yu, Mu-Qing Shen, Qian Wang, Lian-Zhong Yan, Rong-Di Zhang, Meng-Yu Liu, Jian-Yu Qu, Yi-Qing Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China |
title | Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China |
title_full | Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China |
title_fullStr | Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China |
title_full_unstemmed | Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China |
title_short | Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China |
title_sort | analysis of inflammatory parameters and disease severity for 88 hospitalized covid-19 patients in wuhan, china |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415392/ https://www.ncbi.nlm.nih.gov/pubmed/32788884 http://dx.doi.org/10.7150/ijms.47935 |
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