Cargando…

Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury

Metformin (Met) is a major widely used oral glucose lowering drug for the treatment of type 2 diabetes. It is reported that metformin could regulate autophagy in various diseases of cardiovascular system including in I/R injury, diabetic cardiomyopathy and heart failure. Autophagy plays a controvers...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Kai-yu, Que, Jia-qun, Hu, Ze-song, Yu, Yong-wei, Zhou, Ying-ying, Wang, Lei, Xue, Yang-jing, Ji, Kang-ting, Zhang, Xin-min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415420/ https://www.ncbi.nlm.nih.gov/pubmed/32792857 http://dx.doi.org/10.7150/ijbs.40823

Ejemplares similares

Antithrombin III Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Excessive Autophagy in a Phosphoinositide 3-Kinase/Akt-Dependent Manner
por: Huang, Kai-yu, et al.
Publicado: (2019)

Metformin and Sildenafil Attenuate Inflammation and Suppress Apoptosis After Ischemia/Reperfusion Injuries in Rat Urinary Bladder
por: Park, Jong Mok, et al.
Publicado: (2021)

Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy
por: Yu, Yong-Wei, et al.
Publicado: (2022)

Tetrahydroxystilbene Glucoside Suppresses NAPDH Oxidative Stress to Mitigate Apoptosis and Autophagy Induced by Cerebral Ischemia/Reperfusion Injury in Mice
por: Yu, Feng, et al.
Publicado: (2019)

High glucose protects cardiomyocytes against ischaemia/reperfusion injury by suppressing myocardiocyte apoptosis via circHIPK3/miR‐29b/AKT3 signalling
por: Cheng, Nan, et al.
Publicado: (2021)

The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis
por: Gao, Yuan, et al.
Publicado: (2019)

Renal denervation improves cardiac function by attenuating myocardiocyte apoptosis in dogs after myocardial infarction
por: Wang, Li, et al.
Publicado: (2018)

Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat
por: Wu, Hsing-Hui, et al.
Publicado: (2009)

The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy
por: Zhang, Yi, et al.
Publicado: (2019)

Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis
por: Sun, Xiaowei, et al.
Publicado: (2020)

Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress
por: Wu, Shao-ze, et al.
Publicado: (2017)

Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein
por: Wang, Fan, et al.
Publicado: (2014)

MicroRNA-92a Inhibition Attenuates Hypoxia/Reoxygenation-Induced Myocardiocyte Apoptosis by Targeting Smad7
por: Zhang, Busheng, et al.
Publicado: (2014)

Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage
por: Güler, Mustafa Can, et al.
Publicado: (2023)

Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride
por: Ren, JY, et al.
Publicado: (2019)

Electroacupuncture Ameliorates Cerebral Ischemia-Reperfusion Injury by Regulation of Autophagy and Apoptosis
por: Shu, Shi, et al.
Publicado: (2016)

Nicotinamide Adenine Dinucleotide Protects against Spinal Cord Ischemia Reperfusion Injury-Induced Apoptosis by Blocking Autophagy
por: Xie, Lei, et al.
Publicado: (2017)

Effect of Metformin on Myocardial Injury Induced by Hepatic Ischemia-Reperfusion in Rats
por: An, Wen, et al.
Publicado: (2022)

Ameliorative Effect of Sodium Selenite on Silver Nanoparticles-Induced Myocardiocyte Structural Alterations in Rats
por: Ma, Wanrui, et al.
Publicado: (2020)

Sufentanil Preconditioning Protects Against Hepatic Ischemia-Reperfusion Injury by Suppressing Inflammation
por: Lian, Yan-hong, et al.
Publicado: (2019)

Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury
por: Shao, Zi-Qi, et al.
Publicado: (2020)

Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function
por: Chen, Qun, et al.
Publicado: (2021)

Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion
por: Li, Zhenlu, et al.
Publicado: (2018)

Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia-reperfusion rats
por: Shi, Cun-Xian, et al.
Publicado: (2020)

Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPARα Pathway
por: Jiang, Yuhui, et al.
Publicado: (2022)

Autophagy and Liver Ischemia-Reperfusion Injury
por: Cursio, Raffaele, et al.
Publicado: (2015)

Autophagy in hepatic ischemia–reperfusion injury
por: Mao, Benliang, et al.
Publicado: (2023)

Deltonin Ameliorates Cerebral Ischemia/Reperfusion Injury in Correlation with Modulation of Autophagy and Inflammation
por: Zhang, Yi, et al.
Publicado: (2020)

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk
por: Tsai, Chin-Feng, et al.
Publicado: (2021)

Tanshinone-IIA inhibits myocardial infarct via decreasing of the mitochondrial apoptotic signaling pathway in myocardiocytes
por: Fang, Yeqing, et al.
Publicado: (2021)

Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways
por: Cheng, Ping, et al.
Publicado: (2014)

Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis
por: Fu, Hai-rong, et al.
Publicado: (2010)

Effects of Metformin on Ischemia/Reperfusion Injury: New Evidence and Mechanisms
por: Osorio-Llanes, Estefanie, et al.
Publicado: (2023)

Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation
por: Zhang, Jie, et al.
Publicado: (2021)

Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats
por: Jiang, Wen‐Wu, et al.
Publicado: (2017)

Ischemic Preconditioning Promotes Autophagy and Alleviates Renal Ischemia/Reperfusion Injury
por: Xie, Ying, et al.
Publicado: (2018)

Protective Role of mTOR in Liver Ischemia/Reperfusion Injury: Involvement of Inflammation and Autophagy
por: Zhang, Tao, et al.
Publicado: (2019)

Ginsenoside Rg3 Improves Cardiac Function after Myocardial Ischemia/Reperfusion via Attenuating Apoptosis and Inflammation
por: Zhang, Li-ping, et al.
Publicado: (2016)

Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis
por: Cho, Jang-Hee, et al.
Publicado: (2018)

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis
por: Shao, Guangying, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1cm2atv0fgv4rfvia0mcppbblh