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miRNA-based biomarkers, therapies, and resistance in Cancer
MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415433/ https://www.ncbi.nlm.nih.gov/pubmed/32792861 http://dx.doi.org/10.7150/ijbs.47203 |
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author | He, Boxue Zhao, Zhenyu Cai, Qidong Zhang, Yuqian Zhang, Pengfei Shi, Shuai Xie, Hui Peng, Xiong Yin, Wei Tao, Yongguang Wang, Xiang |
author_facet | He, Boxue Zhao, Zhenyu Cai, Qidong Zhang, Yuqian Zhang, Pengfei Shi, Shuai Xie, Hui Peng, Xiong Yin, Wei Tao, Yongguang Wang, Xiang |
author_sort | He, Boxue |
collection | PubMed |
description | MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review. |
format | Online Article Text |
id | pubmed-7415433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-74154332020-08-12 miRNA-based biomarkers, therapies, and resistance in Cancer He, Boxue Zhao, Zhenyu Cai, Qidong Zhang, Yuqian Zhang, Pengfei Shi, Shuai Xie, Hui Peng, Xiong Yin, Wei Tao, Yongguang Wang, Xiang Int J Biol Sci Review MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review. Ivyspring International Publisher 2020-07-19 /pmc/articles/PMC7415433/ /pubmed/32792861 http://dx.doi.org/10.7150/ijbs.47203 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review He, Boxue Zhao, Zhenyu Cai, Qidong Zhang, Yuqian Zhang, Pengfei Shi, Shuai Xie, Hui Peng, Xiong Yin, Wei Tao, Yongguang Wang, Xiang miRNA-based biomarkers, therapies, and resistance in Cancer |
title | miRNA-based biomarkers, therapies, and resistance in Cancer |
title_full | miRNA-based biomarkers, therapies, and resistance in Cancer |
title_fullStr | miRNA-based biomarkers, therapies, and resistance in Cancer |
title_full_unstemmed | miRNA-based biomarkers, therapies, and resistance in Cancer |
title_short | miRNA-based biomarkers, therapies, and resistance in Cancer |
title_sort | mirna-based biomarkers, therapies, and resistance in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415433/ https://www.ncbi.nlm.nih.gov/pubmed/32792861 http://dx.doi.org/10.7150/ijbs.47203 |
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