The protein kinase Akt acts as a coat adaptor in endocytic recycling

Coat proteins play a central role in vesicular transport by binding to cargoes for their sorting into intracellular pathways. Cargo recognition is mediated by components of the coat complex known as adaptor proteins(1–3). We previously showed that ACAP1 (ArfGAP with Coil-coil Ankyrin repeat Protein...

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Autores principales: Hsu, Jia-Wei, Bai, Ming, Li, Kunhua, Yang, Jia-Shu, Chu, Nam, Cole, Philip A., Eck, Michael J., Li, Jian, Hsu, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415567/
https://www.ncbi.nlm.nih.gov/pubmed/32541877
http://dx.doi.org/10.1038/s41556-020-0530-z
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author Hsu, Jia-Wei
Bai, Ming
Li, Kunhua
Yang, Jia-Shu
Chu, Nam
Cole, Philip A.
Eck, Michael J.
Li, Jian
Hsu, Victor W.
author_facet Hsu, Jia-Wei
Bai, Ming
Li, Kunhua
Yang, Jia-Shu
Chu, Nam
Cole, Philip A.
Eck, Michael J.
Li, Jian
Hsu, Victor W.
author_sort Hsu, Jia-Wei
collection PubMed
description Coat proteins play a central role in vesicular transport by binding to cargoes for their sorting into intracellular pathways. Cargo recognition is mediated by components of the coat complex known as adaptor proteins(1–3). We previously showed that ACAP1 (ArfGAP with Coil-coil Ankyrin repeat Protein 1) functions as an adaptor for a clathrin coat complex acting in endocytic recycling(4–6). Here, we find that the protein kinase Akt acts as a co-adaptor in this complex, needed in conjunction with ACAP1 to bind cargo proteins for their recycling. Besides advancing the understanding of endocytic recycling, our findings uncover a fundamentally different way that a kinase acts, being an effector rather than a regulator in a cellular event.
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spelling pubmed-74155672020-12-15 The protein kinase Akt acts as a coat adaptor in endocytic recycling Hsu, Jia-Wei Bai, Ming Li, Kunhua Yang, Jia-Shu Chu, Nam Cole, Philip A. Eck, Michael J. Li, Jian Hsu, Victor W. Nat Cell Biol Article Coat proteins play a central role in vesicular transport by binding to cargoes for their sorting into intracellular pathways. Cargo recognition is mediated by components of the coat complex known as adaptor proteins(1–3). We previously showed that ACAP1 (ArfGAP with Coil-coil Ankyrin repeat Protein 1) functions as an adaptor for a clathrin coat complex acting in endocytic recycling(4–6). Here, we find that the protein kinase Akt acts as a co-adaptor in this complex, needed in conjunction with ACAP1 to bind cargo proteins for their recycling. Besides advancing the understanding of endocytic recycling, our findings uncover a fundamentally different way that a kinase acts, being an effector rather than a regulator in a cellular event. 2020-06-15 2020-08 /pmc/articles/PMC7415567/ /pubmed/32541877 http://dx.doi.org/10.1038/s41556-020-0530-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hsu, Jia-Wei
Bai, Ming
Li, Kunhua
Yang, Jia-Shu
Chu, Nam
Cole, Philip A.
Eck, Michael J.
Li, Jian
Hsu, Victor W.
The protein kinase Akt acts as a coat adaptor in endocytic recycling
title The protein kinase Akt acts as a coat adaptor in endocytic recycling
title_full The protein kinase Akt acts as a coat adaptor in endocytic recycling
title_fullStr The protein kinase Akt acts as a coat adaptor in endocytic recycling
title_full_unstemmed The protein kinase Akt acts as a coat adaptor in endocytic recycling
title_short The protein kinase Akt acts as a coat adaptor in endocytic recycling
title_sort protein kinase akt acts as a coat adaptor in endocytic recycling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415567/
https://www.ncbi.nlm.nih.gov/pubmed/32541877
http://dx.doi.org/10.1038/s41556-020-0530-z
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