Cargando…
Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach
The aim of the present study was to use an in vitro–in silico approach to predict the in vivo acute liver toxicity of monocrotaline and to characterize the influence of its metabolism on its relative toxic potency compared to lasiocarpine and riddelliine. In the absence of data on acute liver toxici...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415757/ https://www.ncbi.nlm.nih.gov/pubmed/32518961 http://dx.doi.org/10.1007/s00204-020-02798-z |