Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle

Rationale: Skeletal muscle insulin resistance is detectable before type 2 diabetes is diagnosed. Exposure to di(2-ethylhexyl) phthalate (DEHP), a typical environmental endocrine-disrupting chemical, is a novel risk factor for insulin resistance and type 2 diabetes. This study aimed to explore insuli...

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Detalles Bibliográficos
Autores principales: Wei, Jie, Hao, Qiongyu, Chen, Chengkun, Li, Juan, Han, Xikui, Lei, Zhao, Wang, Tao, Wang, Yinan, You, Xiang, Chen, Xiaoxuan, Li, Huasheng, Ding, Yuxin, Huang, Weihao, Hu, Yangyang, Lin, Shuirong, Shen, Heqing, Lin, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415800/
https://www.ncbi.nlm.nih.gov/pubmed/32802189
http://dx.doi.org/10.7150/thno.45253

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