Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis

Rationale: MCL-1 is up-regulated in cancer and a target for cancer treatment. How MCL-1 is up-regulated and whether MCL-1 up-regulation plays a role in tumorigenic process is not well-known. Arsenic and benzo(a)pyrene (BaP) are well-recognized lung carcinogens and we recently reported that arsenic a...

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Detalles Bibliográficos
Autores principales: Yang, Ping, Xie, Jie, Li, Yunfei, Lin, Hsuan-Pei, Fenske, William, Clementino, Marco, Jiang, Yiguo, Yang, Chengfeng, Wang, Zhishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415806/
https://www.ncbi.nlm.nih.gov/pubmed/32802178
http://dx.doi.org/10.7150/thno.47897

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