Instability of circular RNAs in clinical tissue samples impairs their reliable expression analysis using RT-qPCR: from the myth of their advantage as biomarkers to reality

Background: Circular RNAs (circRNAs) are a new class of RNAs with medical significance. Compared to that of linear mRNA transcripts, the stability of circRNAs against degradation owing to their circular structure is considered advantageous for their use as biomarkers. As systematic studies on the st...

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Detalles Bibliográficos
Autores principales: Rochow, Hannah, Franz, Antonia, Jung, Monika, Weickmann, Sabine, Ralla, Bernhard, Kilic, Ergin, Stephan, Carsten, Fendler, Annika, Jung, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415809/
https://www.ncbi.nlm.nih.gov/pubmed/32802191
http://dx.doi.org/10.7150/thno.46341

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